Teaching Institute for Public Health "Dr. Andrija Štampar", 10000 Zagreb, Croatia.
Faculty of Agriculture, University of Zagreb, Svetošimunska Cesta 25, 10000 Zagreb, Croatia.
Int J Environ Res Public Health. 2023 Feb 7;20(4):2877. doi: 10.3390/ijerph20042877.
BPA is a plasticizer for the production of polycarbonate plastics and epoxy resins and is widely used in the production of household goods, including food packaging. Free BPA is known to migrate from packaging to food, and its uptake has been associated with adverse health effect, particularly the disruption of endocrine activity. The presence and migration of BPA from plastic consumer products are subject to strict regulation in the EU. The aim of this study is to analyse the migration of BPA from different packaging items and household products sold on the Croatian market. To simulate real life exposure, we treated samples with a food simulant. The analytical performance was confirmed with the EU requirements. BPA levels were assessed in 61 samples by HPLC-FLD and the LOQ of the method was 0.005 mg kg for the food simulant. These results showed that the levels of BPA that migrated to the food simulant were below LOQ and in accordance with the specific migration limit into food, which was defined as 0.05 mg kg for all samples. None of the analysed products presented a health hazard. However, these regulations do not refer to products intended for children's use, in which BPA is banned. Furthermore, regulations require testing before putting products on the market, and previous research shows that possible BPA migration occurs due to various uses, along with a cumulative effect of exposure from even very small concentrations. Therefore, for accurate BPA consumer exposure evaluation and possible health risks, a comprehensive approach is needed.
双酚 A 是生产聚碳酸酯塑料和环氧树脂的增塑剂，广泛用于生产包括食品包装在内的家用产品。已知游离双酚 A 会从包装迁移到食品中，其摄入与不良健康影响有关，特别是内分泌活动的中断。欧盟对塑料消费品中双酚 A 的存在和迁移进行了严格的监管。本研究的目的是分析不同包装物品和在克罗地亚市场上销售的家用产品中双酚 A 的迁移情况。为了模拟实际暴露情况，我们用食品模拟物处理了样品。分析性能符合欧盟要求。我们通过高效液相色谱-荧光检测法（HPLC-FLD）对 61 个样品中的双酚 A 水平进行了评估，该方法对食品模拟物的定量限（LOQ）为 0.005 毫克/千克。这些结果表明，迁移到食品模拟物中的双酚 A 水平低于 LOQ，并且符合特定的迁移限量进入食品，所有样品的迁移限量均为 0.05 毫克/千克。分析的产品均未构成健康危害。然而，这些规定不适用于供儿童使用的产品，因为这些产品禁止使用双酚 A。此外，法规要求在产品投放市场前进行测试，先前的研究表明，由于各种用途以及即使是非常小浓度的暴露也会产生累积效应，因此可能会发生双酚 A 的迁移。因此，需要采取综合方法来准确评估双酚 A 的消费者暴露情况和可能存在的健康风险。
