Abou Omar Tarek F, Sukhn Carol, Fares Souha A, Abiad Mohamad G, Habib Rima R, Dhaini Hassan R
Department of Environmental Health, Faculty of Health Sciences, American University of Beirut, P.O. Box 11-0236, Riad El- Solh, Beirut, 1107 2020, Lebanon.
Department of Pathology and Laboratory Medicine, American University of Beirut, Beirut, Lebanon.
Environ Monit Assess. 2017 Jul;189(7):341. doi: 10.1007/s10661-017-6048-6. Epub 2017 Jun 16.
The use of bisphenol A (BPA) in packaging has grown over the past 50 years despite concerns of its migration into packaged food and beverages, resulting in human exposure. Many studies have reported tumorigenic effects and endocrine alterations associated with BPA in animal models. This study aims at assessing human exposure to BPA from olive oil. A total of 27 olive oil samples were collected from mills and local villagers in the Hasbaya District, a major olive oil harvesting region in Lebanon. Information on storage conditions was also collected. BPA was extracted and quantified by HPLC. Results showed significantly higher BPA levels in olive oil samples stored in plastic vs. non-plastic packaging (mean = 333 vs. 150 μg/kg, p value = 0.006), samples with a plastic storage duration of >1 year compared to those with a storage duration of <1 year (mean = 452 vs. 288 μg/kg, p value = 0.008), and oil samples sourced from locals compared to oil mills (mean = 376 vs. 228 μg/kg, p value = 0.022). Statistically significant higher BPA levels remained for samples stored in plastic vs. non-plastic packaging in the bootstrap multivariable linear regression (B = 121.56, 95% CI 53.44-194.39, p value = 0.009). This is the first report on BPA levels in Mediterranean olive oil. The estimated exposure was 1.38% of the EFSA tolerable daily intake, hence there are no concerns about potential health risks from olive oil consumption.
尽管人们担心双酚A（BPA）会迁移到包装食品和饮料中，导致人体接触，但在过去50年里，其在包装中的使用仍在增加。许多研究报告了在动物模型中与双酚A相关的致癌作用和内分泌改变。本研究旨在评估人类通过橄榄油接触双酚A的情况。从黎巴嫩主要橄榄油产区哈斯巴亚区的工厂和当地村民那里共收集了27个橄榄油样本。还收集了有关储存条件的信息。通过高效液相色谱法提取并定量双酚A。结果显示，储存在塑料包装中的橄榄油样本中的双酚A水平显著高于非塑料包装中的样本（平均值分别为333和150μg/kg，p值=0.006），塑料储存时间>1年的样本与储存时间<1年的样本相比（平均值分别为452和288μg/kg，p值=0.008），以及来自当地的油样与油厂的油样相比（平均值分别为376和228μg/kg，p值=0.022）。在自抽样多变量线性回归中，储存在塑料包装中的样本的双酚A水平在统计学上仍显著更高（B=121.56，95%置信区间53.44 - 194.39，p值=0.009）。这是关于地中海橄榄油中双酚A水平的第一份报告。估计的接触量为欧洲食品安全局可耐受每日摄入量的1.38%，因此无需担心食用橄榄油会带来潜在健康风险。
