National Institute for Nutrition and Health, Chinese Center for Disease Control and Prevention, Beijing 100050, China.
State Key Laboratory of Resources and Environmental Information System, Institute of Geographic Sciences and Natural Resources Research, Chinese Academy of Sciences, Beijing 100101, China.
Int J Environ Res Public Health. 2023 Feb 14;20(4):3328. doi: 10.3390/ijerph20043328.
Hemorrhagic fever with renal syndrome (HFRS) is a rodent-borne disease that has threatened Chinese residents for nearly a century. Although comprehensive prevent and control measures were taken, the HFRS epidemic in China presents a rebounding trend in some areas. Urbanization is considered as an important influencing factor for the HFRS epidemic in recent years; however, the relevant research has not been systematically summarized. This review aims to summarize urbanization-related environmental factors and the HFRS epidemic in China and provide an overview of research perspectives. The literature review was conducted following the PRISMA protocol. Journal articles on the HFRS epidemic in both English and Chinese published before 30 June 2022 were identified from PubMed, Web of Science, and Chinese National Knowledge Infrastructure (CNKI). Inclusion criteria were defined as studies providing information on urbanization-related environmental factors and the HFRS epidemic. A total of 38 studies were included in the review. Changes brought by urbanization on population, economic development, land use, and vaccination program were found to be significantly correlated with the HFRS epidemic. By changing the ecological niche of humans-affecting the rodent population, its virus-carrying rate, and the contact opportunity and susceptibility of populations-urbanization poses a biphasic effect on the HFRS epidemic. Future studies require systematic research framework, comprehensive data sources, and effective methods and models.
肾综合征出血热（HFRS）是一种啮齿动物传播的疾病，近一个世纪以来一直威胁着中国居民的健康。尽管采取了全面的预防和控制措施，但中国的 HFRS 疫情在一些地区呈现反弹趋势。城市化被认为是近年来 HFRS 疫情的一个重要影响因素，但相关研究尚未得到系统总结。本综述旨在总结与城市化相关的环境因素与中国 HFRS 疫情，并提供研究视角概述。文献综述按照 PRISMA 协议进行。从 PubMed、Web of Science 和中国国家知识基础设施（CNKI）中检索了截至 2022 年 6 月 30 日发表的关于 HFRS 疫情的英文和中文期刊文章。纳入标准为提供与城市化相关的环境因素和 HFRS 疫情信息的研究。本综述共纳入 38 项研究。城市化带来的人口、经济发展、土地利用和疫苗接种计划的变化与 HFRS 疫情显著相关。城市化通过改变影响人群的生态位，改变啮齿动物种群的密度、带病毒率以及人群的接触机会和易感性，对 HFRS 疫情产生双重影响。未来的研究需要系统的研究框架、全面的数据源以及有效的方法和模型。
