Department of Clinical Pharmacology, Copenhagen University Hospital Bispebjerg, 2400 Copenhagen, Denmark.
Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark.
Int J Environ Res Public Health. 2023 Feb 16;20(4):3453. doi: 10.3390/ijerph20043453.
The Global Initiative for Asthma (GINA) has presented a shift in pharmacological asthma treatment. The objective of this study was to explore factors influencing a successful switch to a new asthma treatment approach with a focus on asthma patients' attitudes toward treatment change and supportive initiatives. This study was performed as a case study involving a quantitative questionnaire and a qualitative semi-structured interview. A total of 284 responses were collected from the questionnaire, and 141 responses were included. The results showed that asthma patients thought that effectiveness of the new treatment approach, doctor recommendation, and knowledge of the new treatment approach were the most important factors influencing treatment change considerations. Nine interviews were conducted where the main themes were barriers to a shift in asthma treatment, such as effects and side effects of the new treatment, the role of the general practitioner (GP) and conflicts in agreeing on a treatment plan; as well as facilitators to a shift in asthma treatment, such as trust in the GP and easier inhaler use. We found several supportive initiatives, such as consultation with the GP, handing out information leaflets and a consultation at the pharmacy. In conclusion, this study uniquely identified factors that may influence successful treatment shifts in asthma patients that may be instrumental in understanding similar situations in other pharmacological settings.
全球哮喘倡议 (GINA) 提出了药理学哮喘治疗的转变。本研究的目的是探讨影响成功转向新哮喘治疗方法的因素，重点关注哮喘患者对治疗改变的态度和支持性举措。本研究采用案例研究的方式进行，包括定量问卷调查和定性半结构化访谈。共从问卷中收集了 284 份回复，其中包括 141 份有效回复。结果表明，哮喘患者认为新治疗方法的有效性、医生的建议以及对新治疗方法的了解是影响治疗改变考虑的最重要因素。进行了 9 次访谈，主要主题包括哮喘治疗转变的障碍，如新治疗方法的效果和副作用、全科医生 (GP) 的作用以及在治疗方案上存在的冲突；以及哮喘治疗转变的促进因素，如对 GP 的信任和更容易使用吸入器。我们发现了一些支持性举措，如与 GP 咨询、发放宣传册和在药房咨询。总之，本研究独特地确定了可能影响哮喘患者成功治疗转变的因素，这对于理解其他药理学环境中的类似情况可能具有重要意义。
