Department of Public Health, College of Public Health, China Medical University, Taichung 404327, Taiwan.
Department of Neurology, Ching Chyuan Hospital, Taichung 428433, Taiwan.
Int J Environ Res Public Health. 2023 Feb 17;20(4):3563. doi: 10.3390/ijerph20043563.
Previous studies reported an increased risk of benign paroxysmal positional vertigo (BPPV) in patients with migraine. Hence, we aimed to assess the risk of migraine in patients with BPPV. This cohort study was conducted using the Taiwan National Health Insurance Research Database. The BPPV cohort consisted of patients aged <45 years with a diagnosis of BPPV between 2000 and 2009. An age- and sex-matched comparison group free from a history of BPPV or migraine was selected. All cases were followed up from 1 January 2000 to 31 December 2010 or until death or a diagnosis of migraine. The baseline demographic characteristics in both groups were compared using Student's -test and the chi-square test. Cox proportional hazards regression analysis was used to estimate the hazard ratio for migraine in the BPPV cohort compared with the comparison group after adjustment for age, sex, and comorbidities. Notably, 117 of the 1386 participants with BPPV and 146 of the 5544 participants without BPPV developed migraine. After adjustment for age, sex, and comorbidities, BPPV showed an adjusted hazard ratio indicating a 2.96-fold increased risk of migraine (95% confidence interval: 2.30-3.80, < 0.001). We found that BPPV is associated with an increased risk of a migraine diagnosis.
先前的研究报告称，偏头痛患者患良性阵发性位置性眩晕（BPPV）的风险增加。因此，我们旨在评估 BPPV 患者患偏头痛的风险。这项队列研究使用了台湾全民健康保险研究数据库。BPPV 队列包括年龄<45 岁且在 2000 年至 2009 年期间被诊断为 BPPV 的患者。选择了一个无 BPPV 或偏头痛病史且年龄和性别相匹配的对照组。所有病例均随访至 2000 年 1 月 1 日至 2010 年 12 月 31 日或直至死亡或诊断为偏头痛。使用学生 t 检验和卡方检验比较两组的基线人口统计学特征。使用 Cox 比例风险回归分析，在校正年龄、性别和合并症后，比较 BPPV 队列与对照组偏头痛的风险比。值得注意的是，1386 名 BPPV 参与者中有 117 名和 5544 名无 BPPV 参与者中有 146 名发生偏头痛。在校正年龄、性别和合并症后，BPPV 显示调整后的风险比表明偏头痛的风险增加 2.96 倍（95%置信区间：2.30-3.80，<0.001）。我们发现 BPPV 与偏头痛诊断风险增加有关。
