Lee Sang-Hwa, Kim Jong-Ho, Kwon Young-Suk, Lee Jae-June, Sohn Jong-Hee
Department of Neurology, Chuncheon Sacred Heart Hospital, Hallym University College of Medicine, Chuncheon 24253, Korea.
Institute of New Frontier Research Team, College of Medicine, Hallym University College of Medicine, Chuncheon 24253, Korea.
J Pers Med. 2021 Dec 8;11(12):1331. doi: 10.3390/jpm11121331.
Headaches, especially migraines, have been associated with various vestibular symptoms and syndromes. Tinnitus and hearing loss have also been reported to be more prevalent among migraineurs. However, whether headaches, including migraine or non-migraine headaches (nMH), are associated with vestibular and cochlear disorders remains unclear. Thus, we sought to investigate possible associations between headache and vestibulocochlear disorders. We analyzed 10 years of data from the Smart Clinical Data Warehouse. In patients with migraines and nMH, meniere's disease (MD), BPPV, vestibular neuronitis (VN) and cochlear disorders, such as sensorineural hearing loss (SNHL) and tinnitus, were collected and compared to clinical data from controls who had health check-ups without headache. Participants included 15,128 with migraines, 76,773 patients with nMH and controls were identified based on propensity score matching (PSM). After PSM, the odds ratios (OR) in subjects with migraine versus controls were 2.59 for MD, 2.05 for BPPV, 2.98 for VN, 1.74 for SNHL, and 1.97 for tinnitus, respectively ( < 0.001). The OR for MD (1.77), BPPV (1.73), VN (2.05), SNHL (1.40), and tinnitus (1.70) in patients with nMH was also high after matching ( < 0.001). Our findings suggest that migraines and nMH are associated with an increased risk of cochlear disorders in addition to vestibular disorders.
头痛，尤其是偏头痛，已与各种前庭症状和综合征相关联。据报道，耳鸣和听力损失在偏头痛患者中也更为普遍。然而，包括偏头痛或非偏头痛性头痛（nMH）在内的头痛是否与前庭和耳蜗疾病相关仍不清楚。因此，我们试图研究头痛与前庭蜗神经疾病之间可能存在的关联。我们分析了智能临床数据仓库10年的数据。收集了偏头痛和nMH患者中梅尼埃病（MD）、良性阵发性位置性眩晕（BPPV）、前庭神经炎（VN）以及耳蜗疾病（如感音神经性听力损失（SNHL）和耳鸣）的数据，并与无头痛健康体检对照组的临床数据进行比较。参与者包括15128例偏头痛患者、76773例nMH患者，对照组通过倾向得分匹配（PSM）确定。PSM后，偏头痛患者与对照组相比，MD的比值比（OR）为2.59，BPPV为2.05，VN为2.98，SNHL为1.74，耳鸣为1.97（<0.001）。匹配后，nMH患者中MD（1.77）、BPPV（1.73）、VN（2.05）、SNHL（1.40）和耳鸣（1.70）的OR也较高（<0.001）。我们的研究结果表明，偏头痛和nMH除了与前庭疾病相关外，还与耳蜗疾病风险增加有关。
