School of Pharmacy, Southwest Medical University, Luzhou 646000, China.
School of Basic Medical Sciences, Southwest Medical University, Luzhou 646000, China.
Int J Mol Sci. 2023 Feb 5;24(4):3168. doi: 10.3390/ijms24043168.
Megakaryocytes (MKs), a kind of functional hematopoietic stem cell, form platelets to maintain platelet balance through cell differentiation and maturation. In recent years, the incidence of blood diseases such as thrombocytopenia has increased, but these diseases cannot be fundamentally solved. The platelets produced by MKs can treat thrombocytopenia-associated diseases in the body, and myeloid differentiation induced by MKs has the potential to improve myelosuppression and erythroleukemia. Currently, ethnomedicine is extensively used in the clinical treatment of blood diseases, and the recent literature has reported that many phytomedicines can improve the disease status through MK differentiation. This paper reviewed the effects of botanical drugs on megakaryocytic differentiation covering the period 1994-2022, and information was obtained from PubMed, Web of Science and Google Scholar. In conclusions, we summarized the role and molecular mechanism of many typical botanical drugs in promoting megakaryocyte differentiation in vivo, providing evidence as much as possible for botanical drugs treating thrombocytopenia and other related diseases in the future.
巨核细胞（MKs）是一种具有功能的造血干细胞，通过细胞分化和成熟形成血小板以维持血小板平衡。近年来，血小板减少症等血液疾病的发病率有所增加，但这些疾病无法从根本上解决。MKs 产生的血小板可以治疗体内与血小板减少症相关的疾病，而 MKs 诱导的髓系分化具有改善骨髓抑制和红白血病的潜力。目前，民族医学在血液疾病的临床治疗中得到广泛应用，最近的文献报道称，许多植物药可以通过 MK 分化改善疾病状态。本文回顾了 1994-2022 年间植物药对巨核细胞分化的影响，信息来自 PubMed、Web of Science 和 Google Scholar。总之，我们总结了许多典型植物药在体内促进巨核细胞分化的作用和分子机制，为植物药治疗血小板减少症和其他相关疾病提供了尽可能多的证据。
