Błocka-Gumowska Monika, Hus Iwona, Szymczyk Agnieszka
Laboratory Diagnostics Centre, National Medical Institute of the Ministry of Interior and Administration, Wołoska 137 Str., 02-507 Warsaw, Poland.
Department of Hematology, National Medical Institute of the Ministry of Interior and Administration, Wołoska 137 Str., 02-507 Warsaw, Poland.
J Clin Med. 2025 Apr 14;14(8):2681. doi: 10.3390/jcm14082681.
Despite the progress made in recent years in hematological diagnostics, cytological assessment of bone marrow, including the assessment of megakaryocytes, is still an important element of the diagnostic process. It is one of the most accurate methods for detecting even minor abnormalities, which is often superior to histopathological examination in this respect. Although, according to current recommendations, megakaryocytes are not included in the total percentage formula of the myelogram, the assessment of platelet function, morphological features, and quantitative disorders allows for the direction of further diagnostic process. In this article, we present the principles of assessing megakaryocytes in a bone marrow aspirate smear. We also characterize normal megakaryocytes at various stages of megakaryopoiesis, atypical megakaryocytes in pathological and physiological conditions, and cells with a similar morphology to megakaryocytes.
尽管近年来血液学诊断取得了进展，但骨髓的细胞学评估，包括巨核细胞的评估，仍然是诊断过程中的一个重要环节。它是检测即使是微小异常的最准确方法之一，在这方面通常优于组织病理学检查。虽然根据目前的建议，巨核细胞不包括在骨髓细胞分类计数的总百分比公式中，但对血小板功能、形态特征和数量紊乱的评估有助于指导进一步的诊断过程。在本文中，我们介绍了骨髓穿刺涂片巨核细胞评估的原则。我们还描述了巨核细胞生成各阶段的正常巨核细胞、病理和生理条件下的非典型巨核细胞以及形态与巨核细胞相似的细胞。
