Department of Biochemistry, Center of Excellence in Molecular Biology and Regenerative Medicine (CEMR), JSS Medical College, JSS Academy of Higher Education and Research, Mysuru 570004, India.
Department of Gastroenterology, JSS Medical College and Hospital, JSS Academy of Higher Education and Research, Mysuru 570004, India.
Int J Mol Sci. 2023 Feb 7;24(4):3244. doi: 10.3390/ijms24043244.
The pathophysiology of nonalcoholic steatohepatitis (NASH) is complex, owing to its diverse pathological drivers and, until recently, there were no approved drugs for this disease. is a popular herbal medicine used to treat hepatosplenomegaly, hepatitis, and obesity. However, the potential role of in NASH has not yet been scientifically investigated. The administration of via oral gavage lowered body weight, insulin resistance, alanine transaminase (ALT), aspartate transaminase (AST), triglycerides, and total cholesterol in western diet sugar water (WDSW) fed mice but had no effect on chow diet normal water (CDNW) fed mice. improved steatosis, lobular inflammation, and hepatocyte ballooning and resolved NASH in WDSW mice. Furthermore, also alleviated the WDSW-induced Endoplasmic Reticulum stress and oxidative stress, enhanced antioxidant status, and thus reduced inflammation in the treated mice. Of note, these effects were comparable to saroglitazar, the approved drug used to treat human NASH and the positive control used in the study. Thus, our findings indicate the potential of to ameliorate WDSW-induced steatohepatitis, and these preclinical data provide a strong rationale for assessing for the treatment of NASH.
非酒精性脂肪性肝炎（NASH）的病理生理学较为复杂，这是由于其具有多种不同的病理驱动因素，且直到最近都还没有针对该疾病的获批药物。水飞蓟宾是一种常用的草药，用于治疗肝脾肿大、肝炎和肥胖症。然而，水飞蓟宾在 NASH 中的潜在作用尚未得到科学研究。通过口服灌胃给予水飞蓟宾可降低 Western 饮食糖水（WDSW）喂养的小鼠的体重、胰岛素抵抗、丙氨酸转氨酶（ALT）、天冬氨酸转氨酶（AST）、甘油三酯和总胆固醇，但对给予标准饮食正常水（CDNW）的小鼠没有影响。水飞蓟宾可改善 WDSW 诱导的脂肪变性、肝小叶炎症和肝细胞气球样变，并可缓解 WDSW 小鼠的 NASH。此外，水飞蓟宾还可减轻 WDSW 诱导的内质网应激和氧化应激，增强抗氧化状态，从而减轻治疗小鼠的炎症。值得注意的是，这些作用与用于治疗人类 NASH 的获批药物沙格列汀和研究中的阳性对照相当。因此，我们的研究结果表明水飞蓟宾具有改善 WDSW 诱导的脂肪性肝炎的潜力，这些临床前数据为评估水飞蓟宾治疗 NASH 提供了有力的依据。
