妊娠与癌症及其与内质网氨肽酶 1 和 2 的相关性的比较综述
A Comparative Review of Pregnancy and Cancer and Their Association with Endoplasmic Reticulum Aminopeptidase 1 and 2.
机构信息
Department of Microbiology and Immunology, School of Medicine, Virginia Commonwealth University, Richmond, VA 23298, USA.
Department of Biology, Virginia Commonwealth University, Richmond, VA 23298, USA.
出版信息
Int J Mol Sci. 2023 Feb 9;24(4):3454. doi: 10.3390/ijms24043454.
The fundamental basis of pregnancy and cancer is to determine the fate of the survival or the death of humanity. However, the development of fetuses and tumors share many similarities and differences, making them two sides of the same coin. This review presents an overview of the similarities and differences between pregnancy and cancer. In addition, we will also discuss the critical roles that Endoplasmic Reticulum Aminopeptidase (ERAP) 1 and 2 may play in the immune system, cell migration, and angiogenesis, all of which are essential for fetal and tumor development. Even though the comprehensive understanding of ERAP2 lags that of ERAP1 due to the lack of an animal model, recent studies have shown that both enzymes are associated with an increased risk of several diseases, including pregnancy disorder pre-eclampsia (PE), recurrent miscarriages, and cancer. The exact mechanisms in both pregnancy and cancer need to be elucidated. Therefore, a deeper understanding of ERAP's role in diseases can make it a potential therapeutic target for pregnancy complications and cancer and offer greater insight into its impact on the immune system.
妊娠和癌症的根本基础是决定人类的生存或死亡命运。然而，胎儿和肿瘤的发展有许多相似之处和不同之处，使它们成为同一枚硬币的两面。本综述介绍了妊娠和癌症之间的相似之处和不同之处。此外，我们还将讨论内质网氨肽酶 (ERAP) 1 和 2 在免疫系统、细胞迁移和血管生成中可能发挥的关键作用，这些都是胎儿和肿瘤发育所必需的。尽管由于缺乏动物模型，对 ERAP2 的全面了解落后于 ERAP1，但最近的研究表明，这两种酶都与几种疾病的风险增加有关，包括妊娠疾病子痫前期 (PE)、反复流产和癌症。在妊娠和癌症中，都需要阐明其确切的机制。因此，深入了解 ERAP 在疾病中的作用可以使其成为妊娠并发症和癌症的潜在治疗靶点，并更深入地了解其对免疫系统的影响。
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