da Silva Pinto Neto Joaquim, Serra Gustavo Marques, Xavier Luciana Pereira, Santos Agenor Valadares
Laboratory of Biotechnology of Enzymes and Biotransformation, Biological Sciences Institute, Federal University of Pará, Belém 66075-110, PA, Brazil.
Int J Mol Sci. 2025 Jun 25;26(13):6117. doi: 10.3390/ijms26136117.
Biotechnology has increasingly focused on cyanobacteria as these microorganisms are a rich source of secondary metabolites with significant potential for various industries. Cyanobacterial metabolites have been described to have a wide range of biological activities, including cytotoxicity in cancer cells, inhibition of pathogenic bacteria and fungi, and inhibition of various enzymes, demonstrating a great diversity of bioactive compounds. The cyanobacterium is well known for its toxicity and production of the cyanotoxin microcystin. However, another peptide produced by this cyanobacterium, microginins, has significant biotechnological potential. These linear pentapeptides were initially discovered for their angiotensin-converting enzyme (ACE) inhibitory activity. Subsequent studies have explored the full potential of this peptide, revealing its ability to inhibit other enzymes as well. This review aims to compile and systematize the microginins with biotechnological potential described in the literature, as well as outline their main structural characteristics and the predominant methodologies for their isolation and identification.
生物技术越来越关注蓝细菌，因为这些微生物是次生代谢产物的丰富来源，在各个行业具有巨大潜力。蓝细菌代谢产物具有广泛的生物活性，包括对癌细胞的细胞毒性、对病原菌和真菌的抑制作用以及对各种酶的抑制作用，显示出生物活性化合物的巨大多样性。这种蓝细菌以其毒性和蓝藻毒素微囊藻毒素的产生而闻名。然而，这种蓝细菌产生的另一种肽——微囊藻精，具有重要的生物技术潜力。这些线性五肽最初因其对血管紧张素转换酶（ACE）的抑制活性而被发现。随后的研究探索了这种肽的全部潜力，揭示了它也能够抑制其他酶。这篇综述旨在汇编和系统化文献中描述的具有生物技术潜力的微囊藻精，以及概述它们的主要结构特征和分离与鉴定的主要方法。
