X射线和磁共振成像造影剂的抗菌作用：一项体外初步研究。

Antibacterial Effects of X-ray and MRI Contrast Media: An In Vitro Pilot Study.

作者信息

Brönnimann Michael P, Hirzberger Lea, Keller Peter M, Gsell-Albert Monika

机构信息

Department of Diagnostic, Interventional and Paediatric Radiology, Inselspital, Bern University Hospital, University of Bern, 3010 Bern, Switzerland.

Institute for Infectious Diseases, University of Bern, 3010 Bern, Switzerland.

出版信息

Int J Mol Sci. 2023 Feb 9;24(4):3470. doi: 10.3390/ijms24043470.

DOI:10.3390/ijms24043470

PMID:36834880

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9966632/

Abstract

Some radiological contrast agents have been shown to have effects on bacterial growth. In this study, the antibacterial effect and mechanism of action of iodinated X-ray contrast agents (Ultravist 370, Iopamiro 300, Telebrix Gastro 300 and Visipaque) and complexed lanthanide MRI contrast solutions (MultiHance and Dotarem) were tested against six different microorganisms. Bacteria with high and low concentrations were exposed to media containing different contrast media for various lengths of time and at pH 7.0 and 5.5. The antibacterial effect of the media was examined in further tests using agar disk diffusion analysis and the microdilution inhibition method. Bactericidal effects were found for microorganisms at low concentrations and low pH. Reductions were confirmed for and .

摘要

一些放射造影剂已被证明对细菌生长有影响。在本研究中，测试了碘化X射线造影剂（优维显370、碘帕醇300、特利加压素胃肠造影剂300和威视派克）以及络合镧系元素磁共振成像造影剂溶液（钆喷酸葡胺和钆双胺）对六种不同微生物的抗菌效果及作用机制。将高浓度和低浓度的细菌暴露于含有不同造影剂的培养基中，在pH值为7.0和5.5的条件下培养不同时长。在进一步的测试中，使用琼脂扩散法和微量稀释抑制法检测培养基的抗菌效果。发现低浓度和低pH值条件下微生物有杀菌作用。证实了对[具体物质1]和[具体物质2]的减少。