文献检索文档翻译深度研究
Suppr Zotero 插件Zotero 插件
邀请有礼套餐&价格历史记录

新学期，新优惠

限时优惠:9月1日-9月22日

30天高级会员仅需29元

1天体验卡首发特惠仅需5.99元

了解详情
不再提醒
插件&应用
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
高级版
套餐订阅购买积分包
AI 工具
文献检索文档翻译深度研究
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2025

微小 RNA 与唇腭裂相关的基因调控网络。

MicroRNAs and Gene Regulatory Networks Related to Cleft Lip and Palate.

机构信息

Department of Diagnostic & Biomedical Sciences, School of Dentistry, The University of Texas Health Science Center at Houston, Houston, TX 77054, USA.

Center for Craniofacial Research, The University of Texas Health Science Center at Houston, Houston, TX 77054, USA.

出版信息

Int J Mol Sci. 2023 Feb 10;24(4):3552. doi: 10.3390/ijms24043552.

DOI:10.3390/ijms24043552
PMID:36834963
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9958963/
Abstract

Cleft lip and palate is one of the most common congenital birth defects and has a complex etiology. Either genetic or environmental factors, or both, are involved at various degrees, and the type and severity of clefts vary. One of the longstanding questions is how environmental factors lead to craniofacial developmental anomalies. Recent studies highlight non-coding RNAs as potential epigenetic regulators in cleft lip and palate. In this review, we will discuss microRNAs, a type of small non-coding RNAs that can simultaneously regulate expression of many downstream target genes, as a causative mechanism of cleft lip and palate in humans and mice.

摘要

唇腭裂是最常见的先天性出生缺陷之一，其病因复杂。遗传或环境因素，或两者都在不同程度上参与其中，并且唇腭裂的类型和严重程度也有所不同。长期以来的一个问题是环境因素如何导致颅面发育异常。最近的研究强调了非编码 RNA 作为唇腭裂的潜在表观遗传调节剂。在这篇综述中，我们将讨论 microRNAs，作为一种可以同时调节许多下游靶基因表达的小非编码 RNA 类型，作为人类和小鼠唇腭裂的致病机制。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f336/9958963/00bf6b706e53/ijms-24-03552-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f336/9958963/e231b22c3e1c/ijms-24-03552-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f336/9958963/de82a75460cb/ijms-24-03552-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f336/9958963/d31cba913c59/ijms-24-03552-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f336/9958963/00bf6b706e53/ijms-24-03552-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f336/9958963/e231b22c3e1c/ijms-24-03552-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f336/9958963/de82a75460cb/ijms-24-03552-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f336/9958963/d31cba913c59/ijms-24-03552-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f336/9958963/00bf6b706e53/ijms-24-03552-g004.jpg

相似文献

[1]
MicroRNAs and Gene Regulatory Networks Related to Cleft Lip and Palate.

Int J Mol Sci. 2023-2-10

[2]
MicroRNAs as epigenetic regulators of orofacial development.

Differentiation. 2022

[3]
Identification of microRNAs and gene regulatory networks in cleft lip common in humans and mice.

Hum Mol Genet. 2021-9-15

[4]
MicroRNA-655-3p and microRNA-497-5p inhibit cell proliferation in cultured human lip cells through the regulation of genes related to human cleft lip.

BMC Med Genomics. 2019-5-23

[5]
miRNAs as biomarkers of orofacial clefts: A systematic review.

J Oral Pathol Med. 2019-9-17

[6]
Orofacial Cleft and Mandibular Prognathism-Human Genetics and Animal Models.

Int J Mol Sci. 2022-1-16

[7]
Progress of epigenetic modification of SATB2 gene in the pathogenesis of non-syndromic cleft lip and palate.

Asian J Surg. 2024-1

[8]
Orofacial Clefts: Genetics of Cleft Lip and Palate.

Genes (Basel). 2023-8-9

[9]
Genetics of cleft lip and/or cleft palate: association with other common anomalies.

Eur J Med Genet. 2014-8

[10]
Studies with Wnt genes and nonsyndromic cleft lip and palate.

Birth Defects Res A Clin Mol Teratol. 2010-11

引用本文的文献

[1]
miR-383-3p and miR-6951-3p activate cell proliferation through the regulation of genes related to hypertelorism.

Front Cell Dev Biol. 2025-7-24

[2]
Current insights on the genetics and mechanisms of MSX1-associated cleft palate.

Front Dent Med. 2025-7-7

[3]
Fine-tuning of Wnt signaling by RNA surveillance factor Smg5 in the mouse craniofacial development.

iScience. 2025-2-6

[4]
Molecular Regulation of Palatogenesis and Clefting: An Integrative Analysis of Genetic, Epigenetic Networks, and Environmental Interactions.

Int J Mol Sci. 2025-2-6

[5]
Genes Related to Frontonasal Malformations Are Regulated by miR-338-5p, miR-653-5p, and miR-374-5p in O9-1 Cells.

J Dev Biol. 2024-7-6

[6]
Exosomes Derived from Human Palatal Mesenchymal Cells Mediate Intercellular Communication During Palatal Fusion by Promoting Oral Epithelial Cell Migration.

Int J Nanomedicine. 2024

[7]
MicroRNAs in maxillofacial bone modeling and remodeling: implications for malocclusion development and orthodontic treatment.

Front Cell Dev Biol. 2024-3-13

[8]
The presence and distribution of various genes in postnatal CLP-affected palatine tissue.

Maxillofac Plast Reconstr Surg. 2024-1-16

[9]
MicroRNAs in Small Extracellular Vesicles from Amniotic Fluid and Maternal Plasma Associated with Fetal Palate Development in Mice.

Int J Mol Sci. 2023-12-6

[10]
Editorial: Animal models and transgenic technology in Craniofacial biology.

Front Physiol. 2023-10-16

本文引用的文献

[1]
Micronome Revealed miR-205-5p as Key Regulator of VEGFA During Cancer Related Angiogenesis in Hepatocellular Carcinoma.

Mol Biotechnol. 2023-7

[2]
TBX1 targets the miR-200-ZEB2 axis to induce epithelial differentiation and inhibit stem cell properties.

Sci Rep. 2022-11-23

[3]
The long non-sacoding RNA TMEM147-AS1/miR-133b/ZNF587 axis regulates the Warburg effect and promotes prostatic carcinoma invasion and proliferation.

J Gene Med. 2022-11

[4]
Hsa-microRNA-27b-3p inhibits hepatocellular carcinoma progression by inactivating transforming growth factor-activated kinase-binding protein 3/nuclear factor kappa B signalling.

Cell Mol Biol Lett. 2022-9-23

[5]
LINC00511 promotes cervical cancer progression by regulating the miR-497-5p/MAPK1 axis.

Apoptosis. 2022-12

[6]
m hypomethylation as a mechanism for non-syndromic cleft lip and palate.

Epigenetics. 2022-12

[7]
miR-374a-5p alleviates sepsis-induced acute lung injury by targeting ZEB1 via the p38 MAPK pathway.

Exp Ther Med. 2022-7-12

[8]
M2-like tumor-associated macrophages transmit exosomal miR-27b-3p and maintain glioblastoma stem-like cell properties.

Cell Death Discov. 2022-8-4

[9]
MicroRNA-196a-5p overexpression in Wharton's jelly umbilical cord stem cells promotes their osteogenic differentiation and new bone formation in bone defects in the rat calvarium.

Cell Tissue Res. 2022-11

[10]
Identification by RNA-Seq of let-7 clusters as prenatal biomarkers for nonsyndromic cleft lip with palate.

Ann N Y Acad Sci. 2022-10

文献AI研究员

20分钟写一篇综述，助力文献阅读效率提升50倍

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

推荐工具

医学文档翻译智能文献检索