Molecular Inflammation Group, Biomedical Research Institute of Murcia Pascual Parrilla (IMIB), 30120 Murcia, Spain.
General and Digestive System Surgery, Morales Meseguer University Hospital, 30008 Murcia, Spain.
Int J Mol Sci. 2023 Feb 15;24(4):3862. doi: 10.3390/ijms24043862.
Anastomotic leakage (AL) is a defect of the intestinal wall at the anastomotic site and is one of the most severe complications in colorectal surgery. Previous studies have shown that the immune system response plays a significant role in the development of AL. In recent years, DAMPs (damage-associated molecular patterns) have been identified as cellular compounds with the ability to activate the immune system. The NLRP3 inflammasome plays an important role in the inflammatory responses which are mediated by DAMPs such as ATP, HSP proteins or uric acid crystals, when found in extracellular environments. Recent publications suggest that systemic concentration of DAMPs in patients with colorectal surgery may determine the inflammatory process and have a role in the occurrence of AL and other post-surgery complications. This review provides valuable knowledge about the current evidence supporting this hypothesis and highlights the possible role of these compounds in postoperative processes, which could open a new path to explore new strategies to prevent possible post-surgical complications.
吻合口漏（AL）是吻合口肠壁的缺陷，是结直肠手术中最严重的并发症之一。既往研究表明，免疫系统反应在 AL 的发生发展中起重要作用。近年来，损伤相关分子模式（DAMPs）被鉴定为具有激活免疫系统能力的细胞化合物。NLRP3 炎性小体在 DAMPs （如 ATP、HSP 蛋白或尿酸晶体）介导的炎症反应中发挥重要作用，当它们在细胞外环境中被发现时。最近的出版物表明，结直肠手术后患者体内 DAMPs 的系统浓度可能决定炎症过程，并在 AL 和其他手术后并发症的发生中起作用。这篇综述提供了关于支持这一假设的现有证据的有价值的知识，并强调了这些化合物在术后过程中的可能作用，这可能为探索预防可能的术后并发症的新策略开辟了新的途径。
