Institute of Feed Science, College of Animal Sciences, Zhejiang University, Key Laboratory of Molecular Animal Nutrition (Zhejiang University), Ministry of Education, Key Laboratory of Animal Feed and Nutrition of Zhejiang Province, Hangzhou 310058, China.
Int J Mol Sci. 2023 Feb 15;24(4):3900. doi: 10.3390/ijms24043900.
Appreciation of the importance of is growing, and it is becoming increasingly relevant to identify preventive and/or therapeutic solutions targeting gut-liver-brain axes for multiple diseases via . In recent years, and its components such as outer membrane proteins and extracellular vesicles have been known to ameliorate host metabolic health and intestinal homeostasis. However, the impacts of on host health and disease are complex, as both potentially beneficial and adverse effects are mediated by and its derivatives, and in some cases, these effects are dependent upon the host physiology microenvironment and the forms, genotypes, and strain sources of . Therefore, this review aims to summarize the current knowledge of how interacts with the host and influences host metabolic homeostasis and disease progression. Details of will be discussed including its biological and genetic characteristics; biological functions including anti-obesity, anti-diabetes, anti-metabolic-syndrome, anti-inflammation, anti-aging, anti-neurodegenerative disease, and anti-cancer therapy functions; and strategies to elevate its abundance. Key events will be referred to in some specific disease states, and this knowledge should facilitate the identification of -based probiotic therapy targeting multiple diseases via gut-liver-brain axes.
越来越重视对通过肠道-肝脏-大脑轴识别针对多种疾病的预防和/或治疗方法的重要性。近年来，已经知道 及其成分（如外膜蛋白和细胞外囊泡）可以改善宿主的代谢健康和肠道内稳态。然而，由于 和其衍生物介导了潜在有益和不利的影响，并且在某些情况下，这些影响取决于宿主生理微环境以及 的形式、基因型和菌株来源，因此 对宿主健康和疾病的影响是复杂的。因此，本综述旨在总结目前关于 如何与宿主相互作用并影响宿主代谢稳态和疾病进展的知识。将讨论 的详细信息，包括其生物学和遗传学特征；包括抗肥胖、抗糖尿病、抗代谢综合征、抗炎、抗衰老、抗神经退行性疾病和抗癌治疗功能；以及提高其丰度的策略。将在一些特定疾病状态下提到关键事件，这些知识应该有助于通过肠道-肝脏-大脑轴识别针对多种疾病的基于 的益生菌治疗。
