Sector of Cell Collections, Institute of Cytology and Genetics of the Siberian Branch of the Russian Academy of Sciences, 630090 Novosibirsk, Russia.
Natural Sciences Department, Novosibirsk State University, 630090 Novosibirsk, Russia.
Int J Mol Sci. 2023 Feb 15;24(4):3905. doi: 10.3390/ijms24043905.
Human and mouse induced pluripotent stem cells (PSCs) are widely used for studying early embryonic development and for modeling of human diseases. Derivation and studying of PSCs from model organisms beyond commonly used mice and rats may provide new insights into the modeling and treating human diseases. The order Carnivora representatives possess unique features and are already used for modeling human-related traits. This review focuses on the technical aspects of derivation of the Carnivora species PSCs as well as their characterization. Current data on dog, feline, ferret, and American mink PSCs are summarized.
人源和鼠源诱导多能干细胞（iPSCs）被广泛用于研究早期胚胎发育和人类疾病建模。从除常用的小鼠和大鼠以外的模式生物中获得和研究 iPSCs，可能会为人类疾病的建模和治疗提供新的见解。食肉目动物代表具有独特的特征，已经被用于建模人类相关特征。本综述重点介绍了从食肉目物种中获得 iPSCs 的技术方面及其特征。总结了当前关于犬、猫、雪貂和美洲水貂 iPSCs 的数据。
