Qu Yudun, Li Jiaxuan, Zhang Wei, Xia Changliang, Ou Shuanji, Yang Yang, Jiang Nan, Ma Yunfei, Qi Yong, Xu Changpeng
Department of Orthopaedics, Guangdong Second Provincial General Hospital, The Second School of Clinical Medicine, Southern Medical University, Guangzhou 510317, China.
Department of Orthopaedics, Guangdong Second Provincial General Hospital, NO.466 Xingang Road, Haizhu District, Guangzhou 510317, China.
J Pers Med. 2023 Jan 30;13(2):253. doi: 10.3390/jpm13020253.
The purpose of this case-control study was to examine possible links between gene polymorphisms and the risk of developing posttraumatic osteomyelitis (PTOM) in the Chinese population. A total of 306 patients with PTOM and 368 normal controls were genotyped for (rs35829419, rs10754558, rs7525979, rs4612666), (rs1785929, rs1789547, rs1785928, rs12185396, rs681757, rs8299, rs2032206, rs559289), (rs4796793, rs744166, rs1026916, rs2293152, rs1053004), (rs501192, rs580253, rs556205, rs530537), NFKBIA (rs696), (rs4648068), (rs204321), and (rs2569190) using the genotyping technique SNaPshot. The genotype distributions of gene rs10754558 ( = 0.047) and rs7525979 ( = 0.048) significantly differed between the patients and the healthy controls. Additionally, heterozygous models indicated a significant association between rs10754558 and the likelihood of developing PTOM (OR = 1.600, = 0.039), as did recessive and homozygous models of rs7525979 (OR = 0.248, = 0.019 and 0.239, = 0.016, respectively). Collectively, our findings suggest that, in the Chinese population, the risk of developing PTOM was increased by the association between rs10754558 and rs7525979. Therefore, our findings may provide novel insights and guidance in the prevention and development of PTOM.
本病例对照研究的目的是探讨中国人群中基因多态性与创伤后骨髓炎（PTOM）发病风险之间的可能联系。采用SNaPshot基因分型技术，对306例PTOM患者和368例正常对照进行了（rs35829419、rs10754558、rs7525979、rs4612666）、（rs1785929、rs1789547、rs1785928、rs12185396、rs681757、rs8299、rs2032206、rs559289）、（rs4796793、rs744166、rs1026916、rs2293152、rs1053004）、（rs501192、rs580253、rs556205、rs530537）、NFKBIA（rs696）、（rs4648068）、（rs204321）和（rs2569190）的基因分型。患者与健康对照之间基因rs10754558（P = 0.047）和rs7525979（P = 0.048）的基因型分布存在显著差异。此外，杂合子模型表明rs10754558与发生PTOM的可能性之间存在显著关联（OR = 1.600，P = 0.039），rs7525979的隐性和纯合子模型也是如此（分别为OR = 0.248，P = 0.019和0.239，P = 0.016）。总体而言，我们的研究结果表明，在中国人群中，rs10754558和rs7525979之间的关联增加了发生PTOM的风险。因此，我们的研究结果可能为PTOM的预防和发展提供新的见解和指导。
