Department of Orthopaedics, Nanfang Hospital, Southern Medical University, Guangzhou, China 510515.
Guangdong Provincial Key Laboratory of Bone and Cartilage Regenerative Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, China 510515.
Mediators Inflamm. 2020 May 5;2020:3278081. doi: 10.1155/2020/3278081. eCollection 2020.
This case-control study aimed to investigate potential associations between () gene polymorphisms and the risks of developing extremity posttraumatic osteomyelitis (PTOM) in Chinese Han population. Altogether, 189 PTOM patients and 200 healthy controls were genotyped of (rs17561, rs1800587), (rs16944, rs1143627, rs1143634, rs2853550), (rs4251961, rs419598, rs315951), (rs2243248, rs2243250), (rs1800795, rs1800796, rs1800797), (rs4073, rs2227306, rs2227307), (rs3024491, rs3024496, rs1800871, rs1800872, rs1800896), (rs2275913), and (rs763780) using the SNaPshot genotyping method. Statistical differences were observed regarding the genotype distributions of rs16944 ( = 0.049) and rs4251961 ( = 0.007) between the patients and healthy controls. In addition, significant associations were found between rs16944 and the risk of PTOM development by dominant (OR = 1.854, = 0.017), homozygous (OR = 1.831, = 0.041), and heterozygous (OR = 1.869, = 0.022) models, and of rs1143627 by dominant (OR = 1.735, = 0.032) and homozygous (OR = 1.839, = 0.040) models. Moreover, significant links were also identified between rs4251961 and the susceptibility to PTOM by dominant (OR = 0.446, = 0.005) and heterozygous (OR = 0.409, = 0.003) models, and of rs1800796 by dominant (OR = 4.184, = 0.029), homozygous (OR = 4.378, = 0.026), and heterozygous (OR = 3.834, = 0.046) models. The present outcomes demonstrated that rs16944, rs1143627, and rs1800796 associate with increased risks, while rs4251961 links to a decreased risk of PTOM development in Chinese Han population.
本病例对照研究旨在探讨中国汉族人群中 ()基因多态性与发生四肢创伤后骨髓炎（PTOM）风险之间的潜在关联。共对 189 例 PTOM 患者和 200 例健康对照者进行了（rs17561、rs1800587）、（rs16944、rs1143627、rs1143634、rs2853550）、（rs4251961、rs419598、rs315951）、（rs2243248、rs2243250）、（rs1800795、rs1800796、rs1800797）、（rs4073、rs2227306、rs2227307）、（rs3024491、rs3024496、rs1800871、rs1800872、rs1800896）、（rs2275913）和（rs763780）基因多态性的 SNPshot 基因分型。在患者和健康对照组之间，rs16944（=0.049）和 rs4251961（=0.007）的基因型分布存在统计学差异。此外，rs16944 与 PTOM 发病风险呈显性（OR=1.854，=0.017）、纯合（OR=1.831，=0.041）和杂合（OR=1.869，=0.022）模型相关，rs1143627 与显性（OR=1.735，=0.032）和纯合（OR=1.839，=0.040）模型相关。此外，rs4251961 与 PTOM 易感性呈显性（OR=0.446，=0.005）和杂合（OR=0.409，=0.003）模型相关，rs1800796 与显性（OR=4.184，=0.029）、纯合（OR=4.378，=0.026）和杂合（OR=3.834，=0.046）模型相关。本研究结果表明，rs16944、rs1143627 和 rs1800796 与 PTOM 发病风险增加相关，而 rs4251961 与 PTOM 发病风险降低相关。
