Department of Medicine, All India Institute of Medical Sciences, Rishikesh, Uttarakhand, India.
Ann Afr Med. 2022 Apr-Jun;21(2):107-112. doi: 10.4103/aam.aam_70_20.
Heart Failure is a leading cause of mortality worldwide including India. Most cross sectional studies have demonstrated heart failure is associated with deficiency of essential micronutrients including Vitamin D which may play a important role in pathogenesis of ventricular remodelling in heart failure.
Our study performed aimed to determine the effect of supplementation in patients of Heart Failure presenting with Vitamin D deficiency to our institute on severity of Heart Failure.
97 patients of Heart failure coming to our institute were given conventional therapies for Heart Failure along with Vitamin supplementation based on serum Vitamin D levels and followed up for 3 months.
Patient of Heart failure having Vitamin D deficiency had significant reduction in cardiac biomarkers (NT-pro BNP levels), improvement in Left ventricular ejection fraction (LVEF) and more favourable reverse remodelling determined by Left ventricular end diastolic and systolic diameter (LVEDD & LVESD) though quality of life determined by WHODAS 2.0 score did not changed following 12 weeks supplementation of High Dose Vitamin D.
Recognising and treatment of Vitamin D deficiency may determine long term prognosis in patients of Heart Failure.
心力衰竭是全世界，包括印度，导致死亡的主要原因。大多数横断面研究表明，心力衰竭与必需微量营养素（包括维生素 D）缺乏有关，维生素 D 可能在心力衰竭心室重构的发病机制中起重要作用。
我们的研究旨在确定我院心力衰竭伴维生素 D 缺乏症患者补充维生素的效果对心力衰竭严重程度的影响。
对我院 97 例心力衰竭患者进行常规心力衰竭治疗，并根据血清维生素 D 水平进行维生素补充治疗，随访 3 个月。
维生素 D 缺乏的心力衰竭患者的心脏生物标志物（NT-proBNP 水平）显著降低，左心室射血分数（LVEF）改善，左心室舒张末期和收缩末期直径（LVEDD 和 LVESD）的逆向重构更为有利，尽管通过 WHODAS 2.0 评分测定的生活质量在 12 周高剂量维生素 D 补充后没有改变。
识别和治疗维生素 D 缺乏症可能会决定心力衰竭患者的长期预后。
