Correia Ronny Rodrigues, Gameiro Luis Felipe Orsi, Trevisane Nathalia Grion, Bertanha Matheus, Ortolan Erika Veruska Paiva, Lourenção Pedro Luiz Toledo de Arruda
Botucatu Medical School, São Paulo State University-Unesp, Araraquara 01049-010, Brazil.
Unimetrocamp University Center, Campinas 13035-500, Brazil.
Life (Basel). 2023 Feb 2;13(2):430. doi: 10.3390/life13020430.
Constipation is a disorder with a multifactorial origin. Constipation has a varied clinical presentation, including infrequent defecation of bulky stools and episodes of retentive fecal incontinence. Neuromodulation has been used to treat many health problems, with promising results.
To conduct a systematic review of randomized clinical trials based on the effects of transcutaneous neuromodulation in treating constipation and retentive fecal incontinence in children and adolescents.
A systematic review of randomized clinical trials was performed. Medline (PubMed), PEDro, SciELO, Cochrane (CENTRAL), Embase, and Scopus databases were searched from March 2000 to August 2022. We included clinical trials evaluating transcutaneous neuromodulation in children with constipation and fecal incontinence compared or associated with other types of treatment. Two reviewers independently selected relevant studies, assessed the methodological quality, and extracted the data.
Three studies with 164 participants were included in this review. Two meta-analyses were generated based on these studies. These analyses revealed that transcutaneous neuromodulation is an effective adjuvant treatment modality that improves children's constipation and retentive fecal incontinence. The methodological quality of the included studies was classified as high based on the assessment of the quality of evidence, with a high degree of confidence based on the GRADE system.
Transcutaneous neuromodulation is an effective adjuvant treatment modality for children with constipation and retentive fecal incontinence.
便秘是一种多因素起源的病症。便秘有多种临床表现，包括大便干结排便次数少以及潴留性大便失禁发作。神经调节已被用于治疗许多健康问题，并取得了有前景的结果。
基于经皮神经调节对儿童和青少年便秘及潴留性大便失禁的治疗效果，进行一项随机临床试验的系统评价。
进行了一项随机临床试验的系统评价。检索了2000年3月至2022年8月的Medline（PubMed）、PEDro、SciELO、Cochrane（CENTRAL）、Embase和Scopus数据库。我们纳入了评估经皮神经调节治疗便秘和大便失禁儿童并与其他类型治疗进行比较或联合的临床试验。两名评价员独立选择相关研究、评估方法学质量并提取数据。
本评价纳入了3项研究，共164名参与者。基于这些研究进行了两项荟萃分析。这些分析表明，经皮神经调节是一种有效的辅助治疗方式，可改善儿童便秘和潴留性大便失禁。根据证据质量评估，纳入研究的方法学质量被归类为高，基于GRADE系统具有高度可信度。
经皮神经调节是治疗便秘和潴留性大便失禁儿童的一种有效辅助治疗方式。
