Zhao Z Q, Duggan A W
Department of Pharmacology, John Curtin School of Medical Research, Australian National University, Canberra, A.C.T.
Neuropharmacology. 1987 Oct;26(10):1499-502. doi: 10.1016/0028-3908(87)90169-9.
In barbiturate-anaesthetized spinal cats, exaggerated responses of dorsal horn neurones to impulses in unmyelinated primary afferents, were produced by administering naloxone after iontophoretic administration of morphine in the substantia gelatinosa. Clonidine, given both intravenously (5-10 micrograms/kg) and iontophoretically into the substantia gelatinosa, reduced cell responses to pre-naloxone values. The action of clonidine was reversed by idazoxan. This spinal action of clonidine may be an important component in the suppression of the opiate withdrawal syndrome observed in the whole animal.
在巴比妥麻醉的脊髓猫中，在脊髓胶状质中经离子导入给予吗啡后再给予纳洛酮，可使背角神经元对无髓初级传入纤维冲动的反应增强。静脉注射（5 - 10微克/千克）可乐定并经离子导入给予脊髓胶状质，可使细胞反应恢复到纳洛酮给药前的水平。咪唑克生可逆转可乐定的作用。可乐定的这种脊髓作用可能是在整体动物中观察到的阿片类药物戒断综合征抑制作用的一个重要组成部分。
