吗啡与脊髓神经元的脊髓上抑制：吗啡降低麻醉猫紧张性下行抑制的证据
Morphine and supraspinal inhibition of spinal neurones: evidence that morphine decreases tonic descending inhibition in the anaesthetized cat.
作者信息
Duggan A W, Griersmith B T, North R A
出版信息
Br J Pharmacol. 1980 Jul;69(3):461-6. doi: 10.1111/j.1476-5381.1980.tb07035.x.
Abstract
1 A study was made in cats anaesthetized with barbiturate or alpha-chloralose, of the excitation of dorsal horn neurones by impulses in unmyelinated (C) primary afferent fibres of the tibial nerve. 2 Block of conduction in the first lumbar segment by cooling produced large increases in the number of action potentials evoked by C fibre afferents in neurones of more caudal segments. 3 Morphine (0.3 to 1.0 mg/kg) reduced the excitation of neurones by C fibre afferents and also reduced the increase produced by blocking conduction in the spinal cord. Naloxone (0.1 to 0.3 mg/kg) reversed these effects of morphine. 4 This decrease in descending inhibition supports findings in the decerebrate cat but gives no support to the hypothesis that an important component of morphine analgesia is an activation of descending inhibitory pathways.
摘要
- 本研究在使用巴比妥酸盐或α-氯醛糖麻醉的猫身上进行，观察胫神经无髓鞘（C类）初级传入纤维的冲动对背角神经元的兴奋作用。2. 通过冷却阻断第一腰段的传导，可使更靠尾端节段的神经元中由C类纤维传入引起的动作电位数量大幅增加。3. 吗啡（0.3至1.0毫克/千克）可降低C类纤维传入对神经元的兴奋作用，也可降低脊髓传导阻断所产生的增加效应。纳洛酮（0.1至0.3毫克/千克）可逆转吗啡的这些作用。4. 下行抑制的这种降低支持了在去大脑猫身上的发现，但不支持吗啡镇痛的一个重要组成部分是下行抑制通路激活这一假说。
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引用本文的文献
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