二氧化钛和二氧化锆纳米颗粒的胚胎毒性研究
Study of the Embryonic Toxicity of TiO and ZrO Nanoparticles.
作者信息
Lyashenko Elena Nikolaevna, Uzbekova Leyla Djavadovna, Polovinkina Valeri Vladimirovna, Dorofeeva Anastasia Konstantinovna, Ibragimov Said-Umar Sithalil-Ugli, Tatamov Arslan Ayavovich, Avkaeva Albina Gamdullaevna, Mikhailova Anastasia Alekseevna, Tuaeva Inga Shamilevna, Esiev Ruslan Kazbekovich, Mezentsev Sergei Dmitrievich, Gubanova Marina Alexandrovna, Bondarenko Natalya Grigorevna, Maslova Alina Yurievna
机构信息
Department of Obstetrics and Gynecology, Faculty of Pediatrics, S.I. Georgievsky Medical Academy, V.I. Vernadsky Crimean Federal University, 295007 Simferopol, Russia.
Faculty of Pediatrics, Rostov State Medical University, 344009 Rostov-on-Don, Russia.
出版信息
Micromachines (Basel). 2023 Jan 31;14(2):363. doi: 10.3390/mi14020363.
Currently, the widespread use of TiO and ZrO nanoparticles (NPs) in various industries poses a risk in terms of their potential toxicity. A number of experimental studies provide evidence of the toxic effect of TiO and ZrO NPs on biological objects. In order to supplement the level of knowledge and assess the risks of toxicity and danger of TiO and ZrO NPs, we decided to conduct a comprehensive experiment to study the embryonic toxicity of TiO and ZrO NPs in pregnant rats. For the experiment, mongrel white rats during pregnancy received aqueous dispersions of powders of TiO and ZrO NPs at a dose of 100 mg/kg/day. To characterize the effect of TiO and ZrO NPs on females and the postnatal ontogenesis of offspring, a complex of physiological and biochemical research methods was used. The results of the experiment showed that TiO NPs as ZrO NPs (100 mg/kg per os) cause few shifts of similar orientation in the maternal body. Neither TiO NPs nor ZrO NPs have an embryonic and teratogenic effect on the offspring in utero, but both modify its postnatal development.
目前，二氧化钛（TiO）和氧化锆（ZrO）纳米颗粒（NPs）在各行业的广泛应用因其潜在毒性而构成风险。一些实验研究提供了TiO和ZrO NPs对生物物体产生毒性作用的证据。为了补充知识水平并评估TiO和ZrO NPs的毒性风险及危害，我们决定进行一项综合实验，以研究TiO和ZrO NPs对怀孕大鼠的胚胎毒性。在该实验中，怀孕的杂种白鼠每天接受剂量为100 mg/kg的TiO和ZrO NPs粉末的水分散体。为了表征TiO和ZrO NPs对雌性大鼠及其后代产后个体发育的影响，使用了一系列生理生化研究方法。实验结果表明，TiO NPs与ZrO NPs（口服100 mg/kg）在母体中引起了一些相似方向的变化。TiO NPs和ZrO NPs在子宫内对后代均无胚胎毒性和致畸作用，但二者均会改变其产后发育。
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