Université de Lorraine, INRAE, LAE, F-54000 Nancy, France.
Université de Lorraine, SIMPA, F-54000 Nancy, France.
Molecules. 2023 Feb 6;28(4):1552. doi: 10.3390/molecules28041552.
Resistance to conventional treatments renders urgent the discovery of new therapeutic molecules. Plant specialized metabolites such as phenolamides, a subclass of phenolic compounds, whose accumulation in tomato plants is mediated by the biotic and abiotic environment, constitute a source of natural molecules endowed with potential antioxidant, antimicrobial as well as anti-inflammatory properties. The aim of our study was to investigate whether three major phenolamides found in -infested tomato leaves exhibit antimicrobial, cytotoxic and/or anti-inflammatory properties. One of them, ,,-tris(dihydrocaffeoyl)spermine, was specifically synthesized for this study. The three phenolamides showed low to moderate antibacterial activities but were able to counteract the LPS pro-inflammatory effect on THP-1 cells differentiated into macrophages. Extracts made from healthy but not -infested tomato leaf extracts were also able to reduce inflammation using the same cellular approach. Taken together, these results show that phenolamides from tomato leaves could be interesting alternatives to conventional drugs.
对常规治疗的耐药性使得发现新的治疗分子变得尤为紧迫。植物特有的代谢产物，如酚酰胺，是酚类化合物的一个子类，其在番茄植物中的积累受到生物和非生物环境的调节，构成了具有潜在抗氧化、抗菌和抗炎特性的天然分子的来源。我们的研究目的是调查三种在番茄叶片中发现的主要酚酰胺是否具有抗菌、细胞毒性和/或抗炎特性。其中一种， -， -三（二氢咖啡酰基）亚精胺，是专门为这项研究合成的。这三种酚酰胺表现出低到中等的抗菌活性，但能够对抗 LPS 对分化为巨噬细胞的 THP-1 细胞的促炎作用。使用相同的细胞方法，从健康但未感染的番茄叶片提取物中提取的物质也能够减轻炎症。总之，这些结果表明番茄叶片中的酚酰胺可能是传统药物的替代品。
