de Jesus Gonçalo, Marques Lara, Vale Nuno, Mendes Rui Amaral
Centro Regional das Beiras, Universidade Católica Portuguesa, Estrada da Circunvalação, 3504-505 Viseu, Portugal.
OncoPharma Research Group, Center for Health Technology and Services Research (CINTESIS), Rua Doutor Plácido da Costa, 4200-450 Porto, Portugal.
Nanomaterials (Basel). 2023 Feb 12;13(4):706. doi: 10.3390/nano13040706.
The healing process is a dynamic process accompanied by some classical symptoms of inflammation such as redness, swelling, pain, and loss of function. Chitosan is a natural polymer with properties that contribute to tissue healing, with properties that could be applied in periodontal therapy, such as the wound healing of oral mucosa. This experimental split-mouth study aims to assess the possibilities of chitosan influencing the healing process of oral mucosa in eight patients, where the studied group was subjected to two oral surgeries: one with chitosan hydrogel into the socket and other without the biomaterial. A semi-quantitative analysis of the data was performed. Some classic signs of inflammation in a short period of time were observed where chitosan acted, compared to the control. An absence of bleeding was observed in the chitosan cases. According to the literature, chitosan recruits and activates neutrophils and macrophages and stimulates angiogenesis. Hemostatic and antimicrobial activity of chitosan also play an important role in wound healing. Chitosan seems to improve the postoperative quality of patients, allowing rapid wound healing with less complications.
愈合过程是一个动态过程，伴有一些典型的炎症症状，如发红、肿胀、疼痛和功能丧失。壳聚糖是一种天然聚合物，其特性有助于组织愈合，这些特性可应用于牙周治疗，如口腔黏膜的伤口愈合。这项实验性的双侧对照研究旨在评估壳聚糖对8名患者口腔黏膜愈合过程的影响，研究组接受了两次口腔手术：一次在牙槽窝内植入壳聚糖水凝胶，另一次不使用生物材料。对数据进行了半定量分析。与对照组相比，在壳聚糖起作用的部位短时间内观察到了一些典型的炎症迹象。在壳聚糖治疗的病例中未观察到出血现象。根据文献，壳聚糖可募集并激活中性粒细胞和巨噬细胞，并刺激血管生成。壳聚糖的止血和抗菌活性在伤口愈合中也起着重要作用。壳聚糖似乎能改善患者的术后状况，使伤口快速愈合且并发症更少。
