Sharma Saurabh, Kale Tejraj P, Balihallimath Lingaraj J, Motimath Abhishek
Department of Oral and Maxillofacial Surgery, KLE VK Institute of Dental Sciences, Belgaum, Karnataka, India, Phone: +919972789290, e-mail:
Department of Oral and Maxillofacial Surgery, KLE VK Institute of Dental Sciences, Belgaum, Karnataka, India.
J Contemp Dent Pract. 2017 Sep 1;18(9):802-806. doi: 10.5005/jp-journals-10024-2130.
The aim of this study was to evaluate the efficacy of Axiostat Hemostatic Dental dressing in achieving hemostasis postextraction and determining its effect on pain and healing of the extraction wound, compared with control, i.e., conventional method of extraction in patients on oral antiplatelet therapy.
Totally, 40 patients on oral antiplatelet drugs were included in the study and overall 80 extractions were done applying split mouth study design, without altering patient's drug regime. Extraction sites were divided into two groups: Group I received Axiostat Hemostatic Dental Dressing (study site), and group II received conventional method; pressure pack with sterile gauze under biting pressure followed by suturing if required (control site) was used to attain hemostasis.
Extraction sites treated with Axiostat Hemostatic Dressing achieved hemostasis earlier (mean 1 minute 13 seconds) compared with control sites (mean = 14 minutes 1 second), which was also statistically significant (p < 0.001). Postoperative pain was considerably lower and significantly better healing was seen in the study group (p < 0.001) compared with the control.
Axiostat demonstrated to be an effective hemo-static agent that considerably lessens the bleeding time in patients on oral antiplatelet drugs postextraction. In addition, it even offered minimal postoperative pain and improved healing of the extraction wound. On comparing the results of this study with our study on HemCon Dental Dressing, Axiostat Dental Dressing (ADD) is found to be as effective and at par in achieving hemostasis in patients on oral antiplatelet therapy.
The past few decades have seen an upsurge in use of low-dose aspirin either alone or in combination with other drugs. When these patients require dental/maxillofacial treatment, earlier concept of stopping these medications is associated with increased risk of thromboembolic event. The present study highlights an alternative approach using ADD which aids in quick hemostasis, accentuates healing, and reduce postoperative pain.
本研究旨在评估Axiostat止血牙科敷料在拔牙后实现止血的效果，并确定其对拔牙创口疼痛和愈合的影响，与对照组（即口服抗血小板治疗患者的传统拔牙方法）进行比较。
本研究共纳入40例口服抗血小板药物的患者，采用双侧对照研究设计，共进行了80次拔牙，且未改变患者的用药方案。拔牙部位分为两组：第一组使用Axiostat止血牙科敷料（研究部位），第二组采用传统方法；在咬合压力下用无菌纱布进行压迫包扎，必要时进行缝合（对照部位）以实现止血。
与对照部位（平均14分1秒）相比，使用Axiostat止血敷料治疗的拔牙部位止血更早（平均1分13秒），且具有统计学意义（p<0.001）。与对照组相比，研究组术后疼痛明显减轻，愈合情况明显更好（p<0.001）。
Axiostat被证明是一种有效的止血剂，可显著缩短口服抗血小板药物患者拔牙后的出血时间。此外，它还能使术后疼痛降至最低，并促进拔牙创口的愈合。将本研究结果与我们关于HemCon牙科敷料的研究结果进行比较，发现Axiostat牙科敷料（ADD）在口服抗血小板治疗患者实现止血方面同样有效且相当。
在过去几十年中，低剂量阿司匹林单独或与其他药物联合使用的情况有所增加。当这些患者需要进行牙科/颌面治疗时，早期停用这些药物的观念会增加血栓栓塞事件的风险。本研究强调了一种使用ADD的替代方法，该方法有助于快速止血、促进愈合并减轻术后疼痛。
