Department of Epidemiology and Biostatistics, School of Public Health, Jilin University, Changchun 130021, China.
Nutrients. 2023 Feb 12;15(4):918. doi: 10.3390/nu15040918.
Dietary inflammatory index (DII) and handgrip strength (HGS) were correlated, and both were associated with cardiovascular disease (CVD). However, the role of the 10-year CVD risk in the relationship between DII and grip strength remains uncertain.
This study involved 5691 adults from the National Health and Nutrition Examination Survey (NHANES) in 2011-2014. Dietary inflammation, 10-year CVD risk and relative grip strength were assessed by the Dietary Inflammation Index, the Framingham Risk Score (FRS) and handgrip strength adjusted BMI. Linear regression analyses and mediation analysis were used to explore these associations.
Both DII and 10-year CVD risk were negatively associated with relative handgrip strength, and DII was positively associated with 10-year CVD risk. Additionally, 10-year CVD risk partially mediated the association between DII and relative handgrip strength by a 11.8% proportion. Specifically, the mediating effect of the 10-year risk of CVD varied by gender and age.
Reducing the 10-year risk of CVD attenuates the effect of an inflammatory diet on relative grip strength impairment. Therefore, we recommend reducing the effect of inflammatory diet on grip strength impairment by controlling any of the FRS parameters, such as lowering blood pressure and smoking cessation, especially with targeted measures for different populations.
饮食炎症指数（DII）与握力（HGS）相关，两者均与心血管疾病（CVD）相关。然而，DII 和握力之间关系中 10 年 CVD 风险的作用仍不确定。
本研究纳入了 2011-2014 年国家健康和营养检查调查（NHANES）中的 5691 名成年人。通过饮食炎症指数、Framingham 风险评分（FRS）和握力调整 BMI 评估饮食炎症、10 年 CVD 风险和相对握力。采用线性回归分析和中介分析探讨这些关联。
DII 和 10 年 CVD 风险均与相对握力呈负相关，而 DII 与 10 年 CVD 风险呈正相关。此外，10 年 CVD 风险通过 11.8%的比例部分介导了 DII 与相对握力之间的关联。具体而言，CVD 10 年风险的中介作用因性别和年龄而异。
降低 10 年 CVD 风险可减弱炎症饮食对相对握力下降的影响。因此，我们建议通过控制 FRS 参数来降低炎症饮食对握力下降的影响，例如降低血压和戒烟，特别是针对不同人群采取有针对性的措施。
