Huang Zhaoming, Zhang Qiaohui, Zhang Jie, Zhang Renyan, Huang Yujie, Xu Demin
School of Public Health, Xiamen University, Xiamen, Fujian, China.
Zhongshan Hospital (Xiamen), Fudan University, Xiamen, Fujian, China.
Front Cardiovasc Med. 2025 Jun 9;12:1528540. doi: 10.3389/fcvm.2025.1528540. eCollection 2025.
The purpose of this study was to investigate the correlation between plasma homocysteine (Hcy) levels and cardiovascular disease (CVD) in United States adults based on the National Health and Examination Survey (NHANES) database of the United States.
Data from two survey periods (2003-2006) in the NHANES database were used as the research data set. Plasma Hcy levels are considered an independent variable, while CVD is a dependent variable. Weighted logistic regression, linear trend analysis, subgroup analysis and limiting cubic spline plots were used for analysis. A total of 4,418 samples were included.
In the weighted logistic regression model, a significant positive correlation between Hcy level and CVD risk was observed ( for trend = 0.007).The subgroup analysis revealed that various characteristics such as age, race, education level, obesity, alcohol use, diabetes, and hypertension did not affect this positive correlation ( for interaction ≥0.05). The nonlinear association between Hcy level and CVD risk was explored by limiting cubic spline plots, revealing the overall significant trend ( for overall <0.0001) and the significant nonlinear trend ( for nonlinear <0.01).
In this large cross-sectional study, an increase in Hcy levels leads to an increased risk of CVD. There is a nonlinearly positive correlation between Hcy levels and the risk of CVD.
本研究旨在基于美国国家健康与检查调查（NHANES）数据库，调查美国成年人血浆同型半胱氨酸（Hcy）水平与心血管疾病（CVD）之间的相关性。
NHANES数据库中两个调查期（2003 - 2006年）的数据用作研究数据集。血浆Hcy水平被视为自变量，而CVD为因变量。采用加权逻辑回归、线性趋势分析、亚组分析和限制立方样条图进行分析。共纳入4418个样本。
在加权逻辑回归模型中，观察到Hcy水平与CVD风险之间存在显著正相关（趋势检验P = 0.007）。亚组分析显示，年龄、种族、教育水平、肥胖、饮酒、糖尿病和高血压等各种特征均不影响这种正相关（交互作用检验P≥0.05）。通过限制立方样条图探索Hcy水平与CVD风险之间的非线性关联，揭示了总体显著趋势（总体检验P < 0.0001）和显著的非线性趋势（非线性检验P < 0.01）。
在这项大型横断面研究中，Hcy水平升高导致CVD风险增加。Hcy水平与CVD风险之间存在非线性正相关。
