新型硅氧烷接枝藻酸盐作为药物递送支架：载有格列齐特的硅基复合微胶囊的药学表征

Novel Silicone-Grafted Alginate as a Drug Delivery Scaffold: Pharmaceutical Characterization of Gliclazide-Loaded Silicone-Based Composite Microcapsules.

作者信息

Gedawy Ahmed, Luna Giuseppe, Martinez Jorge, Brown Daniel, Al-Salami Hani, Dass Crispin R

机构信息

Curtin Medical School, Curtin University, Bentley 6102, Australia.

Curtin Health Innovation Research Institute, Curtin University, Bentley 6102, Australia.

出版信息

Pharmaceutics. 2023 Feb 4;15(2):530. doi: 10.3390/pharmaceutics15020530.

A novel gliclazide-loaded elastomeric carbohydrate pharmaceutical vehicle was successfully developed. This new siliconized alginate platform showed pseudoplastic rheology with a zeta potential ranging from (-43.8 mV to -75.5 mV). A Buchi-B390 encapsulator was employed to formulate different types of silicone-grafted alginate microcapsules loaded with gliclazide relying on the vibrational ionic gelation technology. The use of tetraethyl orthosilicate (TEOS) to crosslink the silicone elastomer (hydroxy terminated polydimethylsiloxane) of this new platform had improved the gliclazide encapsulation (>92.13% ± 0.76) of the free-flowing composite microcapsules, which showed good mechanical durability (up to 12 h in PBS pH 6.8) and promising results to sustain the drug release.

一种新型载有格列齐特的弹性碳水化合物药物载体被成功研发出来。这种新型的硅化藻酸盐平台呈现假塑性流变学特性，其zeta电位范围为（-43.8毫伏至-75.5毫伏）。采用Buchi-B390包囊机，依靠振动离子凝胶化技术制备了不同类型的载有格列齐特的硅接枝藻酸盐微胶囊。使用原硅酸四乙酯（TEOS）交联该新平台的硅弹性体（羟基封端的聚二甲基硅氧烷）提高了自由流动复合微胶囊中格列齐特的包封率（>92.13%±0.76），这些微胶囊显示出良好的机械耐久性（在pH 6.8的磷酸盐缓冲盐溶液中长达12小时），并且在药物缓释方面取得了有前景的结果。