de la Garza R, McGuire T J, Freedman R, Hoffer B J
University of Colorado Health Sciences Center, Department of Pharmacology, Denver 80262.
Neurosci Lett. 1987 Oct 5;80(3):303-8. doi: 10.1016/0304-3940(87)90472-1.
The agonistic actions of nicotine in the cerebellum were dependent on the type of cerebellar neuron studied. Purkinje cells were inhibited and cerebellar interneurons were excited by pressure-ejected nicotine. The simultaneous iontophoresis of Mg2+ failed to block nicotine agonistic actions on either cell type. Since Mg2+ reduces presynaptic release of neurotransmitters, our findings suggest that the pharmacological actions of nicotine on cerebellar neurons are due to direct postsynaptic mechanisms.
尼古丁在小脑的激动作用取决于所研究的小脑神经元类型。浦肯野细胞受到抑制，而小脑中间神经元则被压力喷射的尼古丁所兴奋。同时进行镁离子的离子电泳未能阻断尼古丁对任何一种细胞类型的激动作用。由于镁离子会减少神经递质的突触前释放，我们的研究结果表明，尼古丁对小脑神经元的药理作用是由于直接的突触后机制。
