Jo Gayoung, Kim Eun Jeong, Hyun Hoon
Department of Biomedical Sciences, Chonnam National University Medical School, Hwasun 58128, Republic of Korea.
BioMedical Sciences Graduate Program (BMSGP), Chonnam National University, Hwasun 58128, Republic of Korea.
Pharmaceutics. 2023 Feb 11;15(2):613. doi: 10.3390/pharmaceutics15020613.
Targeted phototheranostic nanosystems involving both cancer-specific near-infrared (NIR) fluorescence imaging and NIR light-induced phototherapy have shown great potential to improve cancer detection and treatment. In this study, a bifunctional nanocomplex based on low-molecular-weight hyaluronic acid (LMW-HA) and chitosan oligosaccharide lactate (COL) conjugating a zwitterionic NIR dye (ZW800-1) was rationally designed and prepared, and it was simultaneously used to enhance tumor accumulation and photothermal therapy (PTT). When HA-COL-ZW nanocomplexes were intravenously injected into mice bearing NCI-H460 tumors, HA-COL-ZW revealed increased tumor accumulation with prolonged tumor retention. Moreover, the ZW800-1 incorporated in HA-COL-ZW nanocomplexes showed excellent capability to convert NIR light into heat energy at the tumor site, acting as a PTT agent. Therefore, the targeted phototherapeutic HA-COL-ZW nanocomplex is a biocompatible and effective photothermal nanoagent, which could be a good candidate for future clinical use.
涉及癌症特异性近红外（NIR）荧光成像和近红外光诱导光疗的靶向光诊疗纳米系统在改善癌症检测和治疗方面显示出巨大潜力。在本研究中，合理设计并制备了一种基于低分子量透明质酸（LMW-HA）和壳寡糖乳酸盐（COL）并偶联两性离子近红外染料（ZW800-1）的双功能纳米复合物，其同时用于增强肿瘤蓄积和光热疗法（PTT）。当将HA-COL-ZW纳米复合物静脉注射到荷NCI-H460肿瘤的小鼠体内时，HA-COL-ZW显示出肿瘤蓄积增加且在肿瘤内滞留时间延长。此外，掺入HA-COL-ZW纳米复合物中的ZW800-1在肿瘤部位显示出将近红外光转化为热能的优异能力，可作为一种光热治疗剂。因此，靶向光疗HA-COL-ZW纳米复合物是一种生物相容性良好且有效的光热纳米剂，有望成为未来临床应用的优良候选物。
