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用于光热疗法的高分子量和低分子量透明质酸包覆的金纳米双锥体

High and low molecular weight hyaluronic acid-coated gold nanobipyramids for photothermal therapy.

作者信息

Zhao Shuang, Tian Ying, Liu Wenfei, Su Yunyan, Zhang Yunlei, Teng Zhaogang, Zhao Ying, Wang Shouju, Lu Guangming, Yu Zhenghong

机构信息

Department of Medical Oncology, Jinling Hospital, Medical School of Nanjing University Nanjing 210002 P. R. China

Department of Medical Imaging, Jinling Hospital, Medical School of Nanjing University Nanjing 210002 P. R. China

出版信息

RSC Adv. 2018 Feb 28;8(16):9023-9030. doi: 10.1039/c7ra11667e. eCollection 2018 Feb 23.

DOI:10.1039/c7ra11667e
PMID:35539858
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9078663/
Abstract

Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer. It is known that hyaluronic acid (HA) binds CD44 receptors, which are overexpressed on the surface of TNBC cells. To optimize the targeting ability of HA, in this study we coated gold nanobipyramids (GBPs) with high and low molecular weight HA (380 kDa and 102 kDa), named GBPs@h-HA and GBPs@l-HA, respectively. GBPs@l-HA and GBPs@h-HA had excellent stability when dispersed in water and PBS (pH 7.4) for seven days. The HA density was calculated by the ratio of HA to GBPs@l-HA and GBPs@h-HA, which was 13.22 and 4.77, respectively. The two nanoparticles displayed good photostability, which was evaluated by their photothermal performance and similar biocompatibility. Inductively coupled plasma atomic emission spectrometry (ICP-AES) revealed superior cellular uptake of GBPs@h-HA over GBPs@l-HA. Upon 808 nm laser irradiation, the GBPs@h-HA also showed higher therapeutic efficacy than GBPs@l-HA both and . Overall, our study demonstrates that the molecular weight of HA plays an important role in the targeting ability and thus photothermal therapeutic efficacy of HA-coated gold nanobipyramids.

摘要

三阴性乳腺癌（TNBC）是一种侵袭性乳腺癌亚型。已知透明质酸（HA）可结合CD44受体，而CD44受体在TNBC细胞表面过度表达。为了优化HA的靶向能力，在本研究中，我们分别用高分子量HA（380 kDa）和低分子量HA（102 kDa）包覆金纳米双棱锥（GBP），分别命名为GBP@h-HA和GBP@l-HA。GBP@l-HA和GBP@h-HA分散在水和PBS（pH 7.4）中7天时具有优异的稳定性。通过HA与GBP@l-HA和GBP@h-HA的比例计算HA密度，分别为13.22和4.77。通过光热性能和相似的生物相容性评估，这两种纳米颗粒显示出良好的光稳定性。电感耦合等离子体原子发射光谱法（ICP-AES）显示GBP@h-HA比GBP@l-HA具有更高的细胞摄取率。在808 nm激光照射下，GBP@h-HA在[此处原文缺失相关内容]和[此处原文缺失相关内容]方面也显示出比GBP@l-HA更高的治疗效果。总体而言，我们的研究表明，HA的分子量在HA包覆的金纳米双棱锥的靶向能力以及光热治疗效果中起着重要作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2e85/9078663/fc297733cff0/c7ra11667e-f7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2e85/9078663/07dbfd25cb5b/c7ra11667e-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2e85/9078663/aed1bb6b7b87/c7ra11667e-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2e85/9078663/f077629dd33f/c7ra11667e-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2e85/9078663/02b7de870fe6/c7ra11667e-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2e85/9078663/a2afcf561a5b/c7ra11667e-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2e85/9078663/47b3b185d3e4/c7ra11667e-f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2e85/9078663/fc297733cff0/c7ra11667e-f7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2e85/9078663/07dbfd25cb5b/c7ra11667e-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2e85/9078663/aed1bb6b7b87/c7ra11667e-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2e85/9078663/f077629dd33f/c7ra11667e-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2e85/9078663/02b7de870fe6/c7ra11667e-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2e85/9078663/a2afcf561a5b/c7ra11667e-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2e85/9078663/47b3b185d3e4/c7ra11667e-f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2e85/9078663/fc297733cff0/c7ra11667e-f7.jpg

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