Bianchini Marta, Micera Silvestro, Redolfi Riva Eugenio
The BioRobotics Institute, Department of Excellence in Robotics and AI, Scuola Superiore Sant'Anna, 56127 Pisa, Italy.
Translational Neuroengineering, Centre for Neuroprosthetics and Institute of Bioengineering, School of Engineering, École Polytechnique Fédérale de Lausanne (EPFL), 1000 Lausanne, Switzerland.
Pharmaceutics. 2023 Feb 14;15(2):640. doi: 10.3390/pharmaceutics15020640.
When a traumatic event causes complete denervation, muscle functional recovery is highly compromised. A possible solution to this issue is the implantation of a biodegradable polymeric tubular scaffold, providing a biomimetic environment to support the nerve regeneration process. However, in the case of consistent peripheral nerve damage, the regeneration capabilities are poor. Hence, a crucial challenge in this field is the development of biodegradable micro- nanostructured polymeric carriers for controlled and sustained release of molecules to enhance nerve regeneration. The aim of these systems is to favor the cellular processes that support nerve regeneration to increase the functional recovery outcome. Drug delivery systems (DDSs) are interesting solutions in the nerve regeneration framework, due to the possibility of specifically targeting the active principle within the site of interest, maximizing its therapeutical efficacy. The scope of this review is to highlight the recent advances regarding the study of biodegradable polymeric DDS for nerve regeneration and to discuss their potential to enhance regenerative performance in those clinical scenarios characterized by severe nerve damage.
当创伤性事件导致完全去神经支配时，肌肉功能恢复会受到严重影响。解决这一问题的一种可能方法是植入可生物降解的聚合物管状支架，提供一个仿生环境来支持神经再生过程。然而，在周围神经严重损伤的情况下，再生能力较差。因此，该领域的一个关键挑战是开发可生物降解的微纳米结构聚合物载体，用于分子的控释和缓释，以促进神经再生。这些系统的目的是促进支持神经再生的细胞过程，以提高功能恢复效果。药物递送系统（DDS）在神经再生框架中是有趣的解决方案，因为有可能将活性成分特异性地靶向到感兴趣的部位，从而最大限度地提高其治疗效果。本综述的范围是突出关于用于神经再生的可生物降解聚合物DDS研究的最新进展，并讨论它们在那些以严重神经损伤为特征的临床场景中增强再生性能的潜力。
