Bandala Cindy, Cárdenas-Rodríguez Noemi, Mendoza-Torreblanca Julieta Griselda, Contreras-García Itzel Jatziri, Martínez-López Valentín, Cruz-Hernández Teresita Rocio, Carro-Rodríguez Jazmín, Vargas-Hernández Marco Antonio, Ignacio-Mejía Iván, Alfaro-Rodriguez Alfonso, Lara-Padilla Eleazar
Neurociencia Básica, Instituto Nacional de Rehabilitación LGII, Secretaría de Salud, Mexico City 14389, Mexico.
Escuela Superior de Medicina, Instituto Politécnico Nacional, Mexico City 11340, Mexico.
Pharmaceutics. 2023 Feb 18;15(2):693. doi: 10.3390/pharmaceutics15020693.
Dopamine (DA), its derivatives, and dopaminergic drugs are compounds widely used in the management of diseases related to the nervous system. However, DA receptors have been identified in nonneuronal tissues, which has been related to their therapeutic potential in pathologies such as sepsis or septic shock, blood pressure, renal failure, diabetes, and obesity, among others. In addition, DA and dopaminergic drugs have shown anti-inflammatory and antioxidant properties in different kinds of cells.
To compile the mechanism of action of DA and the main dopaminergic drugs and show the findings that support the therapeutic potential of these molecules for the treatment of neurological and non-neurological diseases considering their antioxidant and anti-inflammatory actions.
We performed a review article. An exhaustive search for information was carried out in specialized databases such as PubMed, PubChem, ProQuest, EBSCO, Scopus, Science Direct, Web of Science, Bookshelf, DrugBank, Livertox, and Clinical Trials.
We showed that DA and dopaminergic drugs have emerged for the management of neuronal and nonneuronal diseases with important therapeutic potential as anti-inflammatories and antioxidants.
DA and DA derivatives can be an attractive treatment strategy and a promising approach to slowing the progression of disorders through repositioning.
多巴胺（DA）及其衍生物和多巴胺能药物是广泛用于治疗与神经系统相关疾病的化合物。然而，DA受体已在非神经组织中被发现，这与其在脓毒症或脓毒性休克、血压、肾衰竭、糖尿病和肥胖症等病症中的治疗潜力有关。此外，DA和多巴胺能药物在不同类型的细胞中已显示出抗炎和抗氧化特性。
汇编DA和主要多巴胺能药物的作用机制，并展示支持这些分子因其抗氧化和抗炎作用而具有治疗神经和非神经疾病潜力的研究结果。
我们撰写了一篇综述文章。在PubMed、PubChem、ProQuest、EBSCO、Scopus、Science Direct、Web of Science、Bookshelf、DrugBank、Livertox和Clinical Trials等专业数据库中进行了详尽的信息检索。
我们表明，DA和多巴胺能药物已成为治疗神经和非神经疾病的重要手段，具有作为抗炎药和抗氧化剂的重要治疗潜力。
DA及其衍生物可能是一种有吸引力的治疗策略，也是通过重新定位来减缓疾病进展的一种有前景的方法。
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