Department of Clinical and Experimental Pathology, Wroclaw Medical University, Wroclaw, Poland.
Department of Pathomorphology, 4th Military Clinical Hospital, Wroclaw, Poland.
Cytopathology. 2023 Sep;34(5):503-506. doi: 10.1111/cyt.13225. Epub 2023 Mar 13.
Chordoma is a rare primary central nervous system tumour of notochordal origin. Proper intraoperative or preoperative diagnosis of this entity is crucial for appropriate surgical management. The most common histopathological subtype is conventional chordoma. Cytological characteristics of this subtype are quite distinctive and the diagnosis can be easily made by cytology. There are two particularly important features that are observed in both squash smear and fine needle aspiration specimens: an abundant myxochondroid stroma and cells with large vacuoles, including physaliferous cells. The main differential diagnosis is conventional chondrosarcoma, but in problematic cases immunohistochemical studies are useful to establish the correct diagnosis.
脊索瘤是一种罕见的源自脊索的原发性中枢神经系统肿瘤。正确的术中或术前诊断对适当的手术治疗至关重要。最常见的组织病理学亚型是传统脊索瘤。这种亚型的细胞学特征非常明显，通过细胞学很容易做出诊断。在压碎涂片和细针抽吸标本中都可以观察到两个特别重要的特征：丰富的黏液软骨基质和具有大空泡的细胞，包括泡状细胞。主要的鉴别诊断是传统软骨肉瘤，但在疑难病例中，免疫组织化学研究有助于确立正确的诊断。
