Kruskall M S, Leonard S, Klapholz H
Department of Pathology, Charles A. Dana Research Institute, Boston, Massachusetts.
Obstet Gynecol. 1987 Dec;70(6):938-41.
Forty-eight women in the third trimester of pregnancy who requested autologous blood donations were enrolled in an experimental protocol to evaluate the safety of this procedure. Risk factors suggesting the possible need for postpartum transfusion were present in 17 women, including previous history of transfusion, scheduled cesarean section, placenta previa, and previous pregnancy-induced hypertension. Nine women were unable to meet donation criteria. Thirty-nine participants donated one to three units each. There was one vasovagal reaction among 61 donations. Fetal monitoring performed during each donation to assess cardiovascular and neurologic effects of maternal hypovolemia revealed no abnormalities. Three women with symptomatic postpartum anemias were transfused with autologous blood; two of these patients were identified antepartum as being at risk for possible transfusion. Autologous donation during pregnancy was safe for both mother and fetus. However, the likelihood of postpartum transfusion, while possibly predictable based on antepartum history, was low in this study.
48名妊娠晚期要求进行自体输血的女性被纳入一项实验方案，以评估该操作的安全性。17名女性存在提示可能需要产后输血的风险因素，包括既往输血史、计划剖宫产、前置胎盘和既往妊娠高血压综合征。9名女性不符合献血标准。39名参与者每人捐献了1至3个单位的血液。61次献血中有1次发生血管迷走神经反应。每次献血时进行的胎儿监测，以评估母体血容量减少对心血管和神经系统的影响，结果未发现异常。3名有症状的产后贫血女性接受了自体输血；其中2名患者在产前被确定有输血风险。孕期自体输血对母亲和胎儿均安全。然而，基于产前病史，产后输血的可能性虽有可能预测，但在本研究中较低。
