Dubé Catherine, Latour Catherine, Yanez Jessica Constanzo, Robitaille Nancy
Transfusion Medicine, Héma-Québec, Montréal, Quebec, Canada.
Hôpital Charles-Le Moyne, Centre intégré de santé et de services sociaux, Montérégie-Centre, Greenfield Park, Quebec, Canada.
Transfusion. 2025 Jul;65(7):1264-1272. doi: 10.1111/trf.18288. Epub 2025 Jun 4.
Autologous blood donation (ABD) can be indicated in pregnant individuals with rare blood groups. Yet, unlike hospitals, some blood establishments are reluctant to collect ABDs in this population. Therefore, we evaluated the safety and use of prepartum ABD conducted by a blood establishment.
This retrospective, descriptive cohort study used data from the ABD program in Québec, Canada, and patient medical data reported by treating physicians. Patients were included if they were pregnant, enrolled in Québec's ABD program between January 2010 and January 2021 (i.e., study period) and had a rare blood group.
Twenty-four individuals met the inclusion criteria (mean age at first referral = 31.7 years; 21 [87.5%] first-time donors) and initiated 52 ABDs. Three mild vasovagal reactions (VVRs) were recorded, while no moderate or severe vasovagal reactions (VVRs) were observed. Of the 41 units distributed to the hospitals' blood banks, none were transfused to the mother; 3 were transfused to the fetus or newborn. Most fresh unused units were salvaged and cryopreserved post-delivery (75.0%). Twenty-seven (51.9%) ABDs were made <3 weeks of the expected date of delivery. All seven individuals with available data on iron supplementation had iron deficiency, but only two (28.6%) received intravenous iron.
ABDs may be safely carried out by a blood establishment among pregnant individuals. Transfusion rate is low; however, the majority of donated units are successfully recovered. Improvements will be made to the program by developing specific guidance to target iron deficiency management and timing of donation.
自体献血（ABD）可用于血型罕见的孕妇。然而，与医院不同，一些血站不愿为这一人群采集自体血。因此，我们评估了血站进行的产前自体献血的安全性和使用情况。
这项回顾性描述性队列研究使用了加拿大魁北克省自体献血项目的数据以及治疗医生报告的患者医疗数据。纳入标准为怀孕、在2010年1月至2021年1月（即研究期间）参加魁北克省自体献血项目且血型罕见的患者。
24人符合纳入标准（首次转诊时的平均年龄为31.7岁；21人[87.5%]为首次献血者），共进行了52次自体献血。记录到3例轻度血管迷走神经反应（VVR），未观察到中度或重度血管迷走神经反应（VVR）。在分发给医院血库的41个单位中，没有一个输给母亲；3个输给了胎儿或新生儿。大多数未使用的新鲜单位在分娩后被回收并冷冻保存（75.0%）。27次（51.9%）自体献血在预计分娩日期前<3周进行。所有7名有铁补充剂可用数据的个体都有缺铁情况，但只有2人（28.6%）接受了静脉补铁。
血站可为孕妇安全地进行自体献血。输血率较低；然而，大多数捐献单位都成功回收。将通过制定针对缺铁管理和献血时间的具体指南来改进该项目。
