Chen Shuo, Jiang Sihan, Qiao Dan, Wang Jiangyue, Zhou Qiangqiang, Wu Chunmao, Li Xuefei, Neisiany Rasoul Esmaeely, Sun Lijie, Liu Yuehua, You Zhengwei, Zhu Meifang, Pan Jie
Department of Orthodontics, Shanghai Key Laboratory of Craniomaxillofacial Development and Diseases, Shanghai Stomatological Hospital & School of Stomatology, Fudan University, Shanghai, 200001, P. R. China.
State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Materials Science and Engineering, Institute of Functional Materials, Donghua University, Research Base of Textile Materials for Flexible Electronics and Biomedical Applications (China Textile Engineering Society), Shanghai Engineering Research Center of Nano-Biomaterials and Regenerative Medicine, Shanghai, 201620, P. R. China.
Small Methods. 2023 Apr;7(4):e2201604. doi: 10.1002/smtd.202201604. Epub 2023 Feb 26.
Conductive fibers are vital for next-generation wearable and implantable electronics. However, the mismatch of mechanical, electrical, and biological properties between existing conductive fibers and human tissues significantly retards their further development. Here, the concept of neuro-like fibers to meet these aforementioned requirements is proposed. A new wet spinning process is established to continuously produce pure gelatin hydrogel fibers. The key is the controllable and rapid gelation of spinning solutions based on the salting-out effect, which is inspired by the Chinese food tofu. The resultant fibers exhibit neuro-like features of soft-while-strong mechanical properties, high ionic conductivity, and superior biological properties including biodegradability, biocompatibility, and edibility, which are crucial for implanted applications but seldom reported. Furthermore, all-weather suitable neuro-like fibers with excellent anti-freezing and water retention properties are developed by introducing glycerol for wearable applications. The optical fiber, transient electronics, and electronic data glove made of neuro-like fibers profoundly demonstrate their potential in biomedical applications.
导电纤维对于下一代可穿戴和可植入电子设备至关重要。然而，现有导电纤维与人体组织之间在机械、电学和生物学性能上的不匹配严重阻碍了它们的进一步发展。在此，提出了类神经纤维的概念以满足上述要求。建立了一种新的湿法纺丝工艺来连续生产纯明胶水凝胶纤维。关键在于基于盐析效应的纺丝溶液的可控快速凝胶化，这一灵感来源于中国食品豆腐。所得纤维展现出类神经特征，具有柔软而坚韧的机械性能、高离子导电性以及包括生物可降解性、生物相容性和可食用性在内的优异生物学性能，这些对于植入应用至关重要但鲜有报道。此外，通过引入甘油开发出了具有优异抗冻和保水性能的全天候适用类神经纤维，用于可穿戴应用。由类神经纤维制成的光纤、瞬态电子器件和电子数据手套深刻展示了它们在生物医学应用中的潜力。
