Llerena Zambrano Byron, Renz Aline F, Ruff Tobias, Lienemann Samuel, Tybrandt Klas, Vörös János, Lee Jaehong
Laboratory of Biosensors and Bioelectronics, ETH Zurich, Gloriastrasse 35, Zurich, 8092, Switzerland.
Laboratory of Organic Electronics, Department of Science and Technology, Linköping University, Norrköping, 601 74, Sweden.
Adv Healthc Mater. 2021 Feb;10(3):e2001397. doi: 10.1002/adhm.202001397. Epub 2020 Nov 17.
Research on the field of implantable electronic devices that can be directly applied in the body with various functionalities is increasingly intensifying due to its great potential for various therapeutic applications. While conventional implantable electronics generally include rigid and hard conductive materials, their surrounding biological objects are soft and dynamic. The mechanical mismatch between implanted devices and biological environments induces damages in the body especially for long-term applications. Stretchable electronics with outstanding mechanical compliance with biological objects effectively improve such limitations of existing rigid implantable electronics. In this article, the recent progress of implantable soft electronics based on various conductive nanocomposites is systematically described. In particular, representative fabrication approaches of conductive and stretchable nanocomposites for implantable soft electronics and various in vivo applications of implantable soft electronics are focused on. To conclude, challenges and perspectives of current implantable soft electronics that should be considered for further advances are discussed.
由于其在各种治疗应用中具有巨大潜力，可直接应用于体内并具备多种功能的植入式电子设备领域的研究日益深入。虽然传统的植入式电子产品通常包括刚性和硬的导电材料，但其周围的生物物体是柔软且动态的。植入设备与生物环境之间的机械不匹配会在体内引发损伤，尤其是长期应用时。具有出色的与生物物体机械顺应性的可拉伸电子器件有效地改善了现有刚性植入式电子产品的此类局限性。在本文中，系统地描述了基于各种导电纳米复合材料的植入式软电子器件的最新进展。特别关注了用于植入式软电子器件的导电和可拉伸纳米复合材料的代表性制造方法以及植入式软电子器件的各种体内应用。最后，讨论了当前植入式软电子器件在进一步发展中应考虑的挑战和前景。
