Department of Paediatrics, The First People's Hospital of Xiaoshan District, Hangzhou, Zhejiang, China.
Department of Neonatology, Zhejiang Xiaoshan Hospital, Hangzhou, Zhejiang, China.
Front Endocrinol (Lausanne). 2023 Feb 8;14:1096659. doi: 10.3389/fendo.2023.1096659. eCollection 2023.
Metals can interfere with hormonal functioning through indirect mechanisms and by binding at the receptor site; thus, they may be associated with hormonal changes. However, there have been few studies on the health impact of metal exposure among children and adolescents. Thus, we aimed to examine the associations of blood lead level (BLL) with estradiol (E2) and sex hormone-binding globulin (SHBG) among children and adolescents aged 8-19 years in the National Health and Nutrition Examination Survey (NHANES) database.
This was a cohort study of 2188 individuals from the NHANES. BLL was taken as independent variables, E2 and SHBG as dependent variable. We conducted weighted multivariate linear regression models and smooth curve fittings to evaluate the association between them.
The BLL was significantly positively associated with serum SHBG level in females, especially when the LnBLL quartiles are between Q3 and Q4. There was an inverted U-shaped association between BLL and E2 with the point of inflection at 1.86 μg/L and a U-shaped association between BLL and SHBG with the point of inflection at 1.86 μg/L in female adolescents aged 16-19 years. Meanwhile, In males, there was a positive trend of correlation between BLL and E2 in the 8-11 years, and 16-19 years groups.
This study found an inverted U-shaped association of BLL with E2 and a U-shaped association between BLL and SHBG in female adolescents aged 16-19 years. This indicates that adjusting blood lead exposure to mitigate the effects of lead on growth and development is important for adolescents aged 16-19 years. Controlling the BLL below 1.86 μg/L may minimize the damage to E2.
金属可以通过间接机制和与受体结合来干扰激素功能；因此，它们可能与激素变化有关。然而，关于儿童和青少年金属暴露对健康的影响的研究很少。因此，我们旨在研究美国国家健康和营养检查调查（NHANES）数据库中 8-19 岁儿童和青少年的血铅水平（BLL）与雌二醇（E2）和性激素结合球蛋白（SHBG）之间的关系。
这是一项对 NHANES 数据库中 2188 人的队列研究。BLL 作为自变量，E2 和 SHBG 作为因变量。我们进行了加权多元线性回归模型和光滑曲线拟合，以评估它们之间的关系。
BLL 与女性血清 SHBG 水平呈显著正相关，尤其是在 LnBLL 四分位间距处于 Q3 和 Q4 之间时。BLL 与 E2 之间呈倒 U 型关系，拐点为 1.86μg/L，BLL 与 SHBG 之间呈 U 型关系，拐点为 1.86μg/L，在 16-19 岁的女性青少年中。同时，在 8-11 岁和 16-19 岁的男性中，BLL 与 E2 之间存在正相关趋势。
本研究发现，在 16-19 岁的女性青少年中，BLL 与 E2 呈倒 U 型关系，BLL 与 SHBG 呈 U 型关系。这表明，调整血铅暴露以减轻铅对生长发育的影响对 16-19 岁的青少年很重要。控制 BLL 低于 1.86μg/L 可能会最小化对 E2 的损害。
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