Chemical and Physical Health Risks, Sciensano, J. Wytsmanstraat 14, Brussels 1050, Belgium.
Clinical and Experimental Endocrinology, KU Leuven, Herestraat 49, Leuven 3000, Belgium.
J Nutr Sci. 2023 Feb 21;12:e28. doi: 10.1017/jns.2023.13. eCollection 2023.
The objective of the present study was to assess the dietary intake of steviol glycosides in the Belgian population and to conduct a risk assessment by comparing the estimated intakes to the acceptable daily intake (ADI). A tiered approach was adopted in this study. First, a Tier 2 assessment was performed using maximum permitted levels. Next, the calculations were refined because market share data were used (refined Tier 2). Finally, the actual concentration data of 198 samples purchased from the Belgian market were used for Tier 3 exposure assessment. Based on a Tier 2 assessment, the ADI was exceeded for the high-consumer children population. However, the results of a more refined exposure assessment (Tier 3) of high consumers (P95) within the child, adolescent and adult populations were 13·75, 10 and 6·25 % of the ADI, respectively, using mean analytical results. Even with more conservative refined approaches, the estimated daily intake remained below 20 % of ADI. Flavoured drinks, flavoured fermented milk products and jams, jellies, and marmalades were the top three contributing food groups to steviol intake at 26–49 %, 12–27 % and 5–13 %, respectively. Despite the high concentrations (up to 94 000 mg/kg) of steviol glycosides in tabletop sweeteners, their contribution to the total intake remains low. The impact of the use of food supplements on the total intake was also considered to be limited. It was concluded that there was no risk for the Belgian population related to dietary exposure to steviol glycoside.
本研究旨在评估比利时人群中甜菊糖苷的膳食摄入量,并通过将估计摄入量与可接受日摄入量(ADI)进行比较来进行风险评估。本研究采用了分层方法。首先,使用最大允许水平进行了二级评估。接下来,由于使用了市场份额数据,计算得到了改进(改进后的二级评估)。最后,使用从比利时市场购买的 198 个样本的实际浓度数据进行了三级暴露评估。基于二级评估,高消费者儿童人群的 ADI 被超过。然而,在儿童、青少年和成年高消费者(P95)中进行更精细的暴露评估(三级)的结果分别为 ADI 的 13.75%、10%和 6.25%,使用的是平均分析结果。即使采用更保守的精细化方法,估计的每日摄入量仍低于 ADI 的 20%。调味饮料、调味发酵乳产品和果酱、果冻和蜜饯是甜菊醇摄入量最高的前三大食物组,分别占 26-49%、12-27%和 5-13%。尽管桌面甜味剂中的甜菊糖苷浓度很高(高达 94000mg/kg),但其对总摄入量的贡献仍然较低。还考虑了食品补充剂的使用对总摄入量的影响,认为其影响有限。因此,比利时人群不存在与膳食摄入甜菊糖苷相关的风险。