Wang Xiaowei, Zhang Na, Li Meihua, Hong Tao, Meng Wei, Ouyang Taohui
Department of Neurosurgery, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, P.R. China.
Department of The Second Clinical Medical College of Nanchang University, Nanchang, Jiangxi 330006, P.R. China.
Oncol Lett. 2023 Feb 8;25(3):123. doi: 10.3892/ol.2023.13709. eCollection 2023 Mar.
Ubiquitin C-terminal hydrolase-L1 (UCH-L1), a member of the lesser-known deubiquitinating enzyme family, has deubiquitinase and ubiquitin (Ub) ligase activity and the role of stabilizing Ub. UCH-L1 was first discovered in the brain and is associated with regulating cell differentiation, proliferation, transcriptional regulation and numerous other biological processes. UCH-L1 is predominantly expressed in the brain and serves a role in tumor promotion or inhibition. There is still controversy about the effect of UCH-L1 dysregulation in cancer and its mechanisms are unknown. Extensive research to investigate the mechanism of UCH-L1 in different types of cancer is key for the future treatment of UCH-L1-associated cancer. The present review details the molecular structure and function of UCH-L1. The role of UCH-L1 in different types of cancer is also summarized and how novel treatment targets provide a theoretical foundation in cancer research is discussed.
泛素羧基末端水解酶L1（UCH-L1）是鲜为人知的去泛素化酶家族的成员，具有去泛素酶和泛素（Ub）连接酶活性以及稳定Ub的作用。UCH-L1最初在大脑中被发现，与调节细胞分化、增殖、转录调控及许多其他生物学过程有关。UCH-L1主要在大脑中表达，在肿瘤促进或抑制中发挥作用。UCH-L1失调在癌症中的作用仍存在争议，其机制尚不清楚。广泛研究UCH-L1在不同类型癌症中的作用机制是未来治疗UCH-L1相关癌症的关键。本综述详细介绍了UCH-L1的分子结构和功能。还总结了UCH-L1在不同类型癌症中的作用，并讨论了新的治疗靶点如何为癌症研究提供理论基础。
