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什么是微生物群?一个社交网络的描述。

What Is the Microbiome? A Description of a Social Network.

作者信息

van Praagh J B, Havenga Klaas

机构信息

Department of Surgery, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.

出版信息

Clin Colon Rectal Surg. 2023 Feb 8;36(2):91-97. doi: 10.1055/s-0043-1760863. eCollection 2023 Mar.

DOI:10.1055/s-0043-1760863
PMID:36844706
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9946720/
Abstract

The gut microbiome has coevolved with its hosts over the years, forming a complex and symbiotic relationship. It is formed by what we do, what we eat, where we live, and with whom we live. The microbiome is known to influence our health by training our immune system and providing nutrients for the human body. However, when the microbiome becomes out of balance and dysbiosis occurs, the microorganisms within can cause or contribute to diseases. This major influencer on our health is studied intensively, but it is unfortunately often overlooked by the surgeon and in surgical practice. Because of that, there is not much literature about the microbiome and its influence on surgical patients or procedures. However, there is evidence that it plays a major role, showing that it needs to be a topic of interest for the surgeon. This review is written to show the surgeon the importance of the microbiome and why it should be taken into consideration when preparing or treating patients.

摘要

多年来,肠道微生物群与其宿主共同进化,形成了一种复杂的共生关系。它由我们的行为、饮食、居住地点以及与我们共同生活的人所塑造。众所周知,微生物群通过训练我们的免疫系统和为人体提供营养来影响我们的健康。然而,当微生物群失衡并发生失调时,其中的微生物会导致疾病或促使疾病发生。这个对我们健康有重大影响的因素得到了深入研究,但不幸的是,外科医生和外科实践中常常忽视它。因此,关于微生物群及其对外科患者或手术的影响的文献并不多。然而,有证据表明它起着重要作用,这表明它应该成为外科医生关注的话题。撰写这篇综述是为了向外科医生展示微生物群的重要性,以及在准备或治疗患者时为何应将其考虑在内。

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Brief Bioinform. 2023 Nov 22;25(1). doi: 10.1093/bib/bbad448.

本文引用的文献

1
Mechanical Bowel Preparation Is a Risk Factor for Postoperative Delirium as It Alters the Gut Microbiota Composition: A Prospective Randomized Single-Center Study.机械性肠道准备是术后谵妄的一个危险因素,因为它会改变肠道微生物群组成:一项前瞻性随机单中心研究。
Front Aging Neurosci. 2022 Apr 4;14:847610. doi: 10.3389/fnagi.2022.847610. eCollection 2022.
2
Environmental factors shaping the gut microbiome in a Dutch population.塑造荷兰人群肠道微生物群的环境因素
Nature. 2022 Apr;604(7907):732-739. doi: 10.1038/s41586-022-04567-7. Epub 2022 Apr 13.
3
Acute and persistent effects of commonly used antibiotics on the gut microbiome and resistome in healthy adults.常用抗生素对健康成年人肠道微生物组和抗药组的急性和持续影响。
Cell Rep. 2022 Apr 12;39(2):110649. doi: 10.1016/j.celrep.2022.110649.
4
Combined effects of host genetics and diet on human gut microbiota and incident disease in a single population cohort.宿主遗传学和饮食对单个人群队列中人类肠道微生物群和疾病发病的综合影响。
Nat Genet. 2022 Feb;54(2):134-142. doi: 10.1038/s41588-021-00991-z. Epub 2022 Feb 3.
5
Gut microbiome and health: mechanistic insights.肠道微生物组与健康:作用机制的见解。
Gut. 2022 May;71(5):1020-1032. doi: 10.1136/gutjnl-2021-326789. Epub 2022 Feb 1.
6
Impact of gastrointestinal surgery upon the gut microbiome: A systematic review.胃肠手术对肠道微生物群的影响:一项系统评价。
Surgery. 2022 May;171(5):1331-1340. doi: 10.1016/j.surg.2021.10.014. Epub 2021 Nov 19.
7
Fecal Microbiota Transplantation Protects the Intestinal Mucosal Barrier by Reconstructing the Gut Microbiota in a Murine Model of Sepsis.粪便微生物群移植通过重建脓毒症小鼠模型中的肠道微生物群来保护肠道黏膜屏障。
Front Cell Infect Microbiol. 2021 Sep 22;11:736204. doi: 10.3389/fcimb.2021.736204. eCollection 2021.
8
Long-term dietary patterns are associated with pro-inflammatory and anti-inflammatory features of the gut microbiome.长期的饮食模式与肠道微生物组的促炎和抗炎特征有关。
Gut. 2021 Jul;70(7):1287-1298. doi: 10.1136/gutjnl-2020-322670. Epub 2021 Apr 2.
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New Insights Into the Cancer-Microbiome-Immune Axis: Decrypting a Decade of Discoveries.癌症-微生物组-免疫轴的新见解:解码十年的发现。
Front Immunol. 2021 Feb 23;12:622064. doi: 10.3389/fimmu.2021.622064. eCollection 2021.
10
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Front Microbiol. 2021 Jan 28;12:611413. doi: 10.3389/fmicb.2021.611413. eCollection 2021.