Liu Shanshan, Song Qiangsheng, Zhang Chenchen, Li Mengwan, Li Zhenzhen, Liu Yudong, Xu Li, Xie Xiaofei, Zhao Lili, Zhang Rongxiu, Wang Qinglong, Zeng Guojin, Zhang Yifan, Zhang Kai
Department of Stomatology, The First Affiliated Hospital of Bengbu Medical College, Bengbu, China.
Anhui Key Laboratory of Infection and Immunity, Bengbu Medical College, Bengbu, China.
J Oral Microbiol. 2023 Feb 20;15(1):2180927. doi: 10.1080/20002297.2023.2180927. eCollection 2023.
We aimed to explore saliva microbiome alterations in dental fluorosis population.
The prevalence of dental fluorosis was examined in 957 college students. Dean's fluorosis index was used to evaluate the dental fluorosis status. Changes in the composition of the salivary microbiome were assessed in a subset of these patients (100 healthy controls, 100 dental fluorosis patients).
Dental fluorosis affected 47% of the student sample, and incidence was unrelated to gender. Compared with healthy controls, the microbiota of patients with dental fluorosis exhibited increased diversity, with increased abundance of , , , , , and decreased abundance of , , , and . Function analyses showed increases in arginine biosynthesis in patients affected by dental fluorosis, together with reductions in amino sugar and nucleotide sugar metabolism, fructose and mannose metabolism, and starch and sucrose metabolism.
These results suggest that there are striking differences in salivary microbiome between healthy controls and dental fluorosis patients. Dental fluorosis may contribute to periodontitis and systemic lung diseases. There is a need for cohort studies to determine whether altering the salivary microbiota in dental fluorosis patients can alter the development of oral or systemic diseases.
我们旨在探究氟斑牙人群唾液微生物群的变化。
对957名大学生进行氟斑牙患病率检查。采用迪恩氟斑牙指数评估氟斑牙状况。在这些患者的一个子集中（100名健康对照者、100名氟斑牙患者）评估唾液微生物群组成的变化。
氟斑牙影响了47%的学生样本，且发病率与性别无关。与健康对照者相比，氟斑牙患者的微生物群多样性增加， 、 、 、 、 丰度增加，而 、 、 丰度降低。功能分析表明，氟斑牙患者精氨酸生物合成增加，同时氨基糖和核苷酸糖代谢、果糖和甘露糖代谢以及淀粉和蔗糖代谢减少。
这些结果表明，健康对照者和氟斑牙患者的唾液微生物群存在显著差异。氟斑牙可能导致牙周炎和全身性肺部疾病。需要进行队列研究以确定改变氟斑牙患者的唾液微生物群是否会改变口腔或全身性疾病的发展。
