Woyesa Shiferaw Bekele, Amente Kellemuwa Desalegn
School of Medical Laboratory Science, Jimma University, Jimma, Ethiopia.
Jimma University Medical Center, Jimma University, Jimma, Ethiopia.
Infect Drug Resist. 2023 Feb 20;16:1061-1068. doi: 10.2147/IDR.S403133. eCollection 2023.
Transmission dynamic model is a concrete structure to describe and investigate the complex system of host-pathogen interactions. Hepatitis C virus (HCV) is a blood-borne virus that is transmitted from infectious to susceptible individuals when they come into contact with HCV-contaminated equipment. Injecting drug use is the most known transmission route, and about 80% of new HCV cases have been confirmed as having acquired HCV infection via drug injection.
The main objective of this review paper was to review the importance of HCV dynamic transmission model, that enables the readers to understand the mechanism how HCV is transmissible from infectious to susceptible hosts and the effective controlling strategies.
PubMed Central, Google Scholar, and Web of Science electronic databases have been used to search data by using key terms like "HCV transmission model among people who inject drug (PWID)", HCV potential herd immunity", and "basic reproductive number for HCV transmission in PWID." Data from research findings other than English version have been excluded from being used, and the most recently published data have been considered to be included.
HCV belongs to the genus within the family. HCV infection is acquired when the susceptible individuals in populations come into contact with medical equipment such as shared syringes and needles, or swabs contaminated with infected blood. Construction of HCV transmission dynamic model is very significant in order to predict the duration and magnitude of its epidemic and to evaluate the potential impact of intervention. Comprehensive harm reduction and care/support service strategies are the best approach for intervention regarding HCV infection transmission among PWID.
传播动力学模型是描述和研究宿主 - 病原体相互作用复杂系统的具体结构。丙型肝炎病毒（HCV）是一种血源性病毒，当感染个体与受HCV污染的设备接触时，会传播给易感个体。注射吸毒是最常见的传播途径，约80%的新发HCV病例已被证实是通过药物注射感染HCV的。
本综述文章的主要目的是回顾HCV动态传播模型的重要性，使读者了解HCV从感染宿主传播到易感宿主的机制以及有效的控制策略。
利用PubMed Central、谷歌学术和科学网电子数据库，通过使用“注射吸毒者（PWID）中的HCV传播模型”、“HCV潜在群体免疫”和“PWID中HCV传播的基本繁殖数”等关键词搜索数据。非英文版本的研究结果数据被排除使用，且纳入了最近发表的数据。
HCV属于该科内的属。当人群中的易感个体接触到共用注射器和针头或被感染血液污染的拭子等医疗设备时，就会感染HCV。构建HCV传播动力学模型对于预测其流行的持续时间和规模以及评估干预措施的潜在影响非常重要。全面的减少伤害和护理/支持服务策略是针对PWID中HCV感染传播进行干预的最佳方法。
