• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

模拟治疗依从性挑战对丙型肝炎病毒传播动力学的影响。

Modeling the effects of treatment adherence challenges on the transmission dynamics of hepatitis C virus.

作者信息

Mupedza Tinashe Victor, Mhlanga Laurette, Mamutse Dennis, Helikumi Mlyashimbi, Lolika Paride Oresto, Murambiwa Shingirai Tangakugara, Mhlanga Adquate

机构信息

Department of Mathematics, University of Zimbabwe, Harare, Zimbabwe.

Department of Preventive Medicine and Institute for Global Health, Northwestern University, Chicago, Illinois, United States of America.

出版信息

PLoS One. 2025 Aug 8;20(8):e0329543. doi: 10.1371/journal.pone.0329543. eCollection 2025.

DOI:10.1371/journal.pone.0329543
PMID:40779594
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12334037/
Abstract

Infectious disease modeling is crucial for predicting disease progression over time and helps guide decision makers in public health policy. Hepatitis C virus (HCV) prevalence is still increasing in Zimbabwe, a low-middle-income country (LMIC), despite the availability of effective treatments, and the reasons for this increase are not well understood. Our study employed a mathematical model to explain the impact of poor treatment adherence on HCV transmission dynamics in Zimbabwe. We computed the basic reproduction number ([Formula: see text]), a vital metric of disease spread. Equilibrium states of the model were determined, and their stability was investigated. The study demonstrated that an adherence level exceeding 52% causes the reproduction number to drop below 1, curtailing further spread. Our HCV model indicates that variations in re-susceptibility minimally impact outcomes, suggesting that re-susceptibility can often be excluded in such analyses. Our model unraveled the synergistic impact of simultaneously enhancing the recovery rate of acutely infected individuals and treatment adherence on reducing [Formula: see text]. The study underlines the pressing need for stronger health interventions, including patient education, financial assistance, and rigorous monitoring, to improve treatment adherence. These interventions are paramount in curbing HCV proliferation, particularly in LMICs like Zimbabwe, and can serve as a template for similar settings globally.

摘要

传染病建模对于预测疾病随时间的进展至关重要，并有助于指导公共卫生政策的决策者。尽管有有效的治疗方法，但在津巴布韦这个低收入和中等收入国家（LMIC），丙型肝炎病毒（HCV）的流行率仍在上升，而这种上升的原因尚不清楚。我们的研究采用了一个数学模型来解释治疗依从性差对津巴布韦HCV传播动态的影响。我们计算了基本再生数（[公式：见正文]），这是疾病传播的一个关键指标。确定了模型的平衡状态，并研究了它们的稳定性。研究表明，超过52%的依从水平会使再生数降至1以下，从而遏制进一步传播。我们的HCV模型表明，重新易感性的变化对结果的影响最小，这表明在这类分析中通常可以排除重新易感性。我们的模型揭示了同时提高急性感染个体的康复率和治疗依从性对降低[公式：见正文]的协同影响。该研究强调迫切需要加强卫生干预措施，包括患者教育、财政援助和严格监测，以提高治疗依从性。这些干预措施对于遏制HCV的扩散至关重要，特别是在像津巴布韦这样的低收入和中等收入国家，并且可以作为全球类似情况的模板。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9443/12334037/19326a3db897/pone.0329543.g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9443/12334037/6795bea24666/pone.0329543.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9443/12334037/92b3b88e1b8b/pone.0329543.g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9443/12334037/bc939d01eeed/pone.0329543.g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9443/12334037/6afe7cf1a15c/pone.0329543.g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9443/12334037/4ce86e06c095/pone.0329543.g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9443/12334037/29bc7c41034c/pone.0329543.g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9443/12334037/8f2b354f3628/pone.0329543.g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9443/12334037/bc7322c3a715/pone.0329543.g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9443/12334037/3e552fee4d67/pone.0329543.g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9443/12334037/586bb8d3218f/pone.0329543.g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9443/12334037/4a07e1bd9d23/pone.0329543.g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9443/12334037/19326a3db897/pone.0329543.g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9443/12334037/6795bea24666/pone.0329543.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9443/12334037/92b3b88e1b8b/pone.0329543.g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9443/12334037/bc939d01eeed/pone.0329543.g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9443/12334037/6afe7cf1a15c/pone.0329543.g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9443/12334037/4ce86e06c095/pone.0329543.g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9443/12334037/29bc7c41034c/pone.0329543.g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9443/12334037/8f2b354f3628/pone.0329543.g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9443/12334037/bc7322c3a715/pone.0329543.g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9443/12334037/3e552fee4d67/pone.0329543.g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9443/12334037/586bb8d3218f/pone.0329543.g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9443/12334037/4a07e1bd9d23/pone.0329543.g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9443/12334037/19326a3db897/pone.0329543.g012.jpg

相似文献

1
Modeling the effects of treatment adherence challenges on the transmission dynamics of hepatitis C virus.模拟治疗依从性挑战对丙型肝炎病毒传播动力学的影响。
PLoS One. 2025 Aug 8;20(8):e0329543. doi: 10.1371/journal.pone.0329543. eCollection 2025.
2
NIH Consensus Statement on Management of Hepatitis C: 2002.美国国立卫生研究院关于丙型肝炎管理的共识声明：2002年。
NIH Consens State Sci Statements. 2002;19(3):1-46.
3
Interventions to improve safe and effective medicines use by consumers: an overview of systematic reviews.改善消费者安全有效用药的干预措施：系统评价概述
Cochrane Database Syst Rev. 2014 Apr 29;2014(4):CD007768. doi: 10.1002/14651858.CD007768.pub3.
4
Direct-acting antivirals for chronic hepatitis C.用于慢性丙型肝炎的直接作用抗病毒药物。
Cochrane Database Syst Rev. 2017 Sep 18;9(9):CD012143. doi: 10.1002/14651858.CD012143.pub3.
5
Community views on mass drug administration for soil-transmitted helminths: a qualitative evidence synthesis.社区对土壤传播蠕虫群体药物给药的看法：定性证据综合分析
Cochrane Database Syst Rev. 2025 Jun 20;6:CD015794. doi: 10.1002/14651858.CD015794.pub2.
6
Pharmacological interventions for acute hepatitis C infection: an attempted network meta-analysis.急性丙型肝炎感染的药物干预：一项网状Meta分析尝试
Cochrane Database Syst Rev. 2017 Mar 13;3(3):CD011644. doi: 10.1002/14651858.CD011644.pub2.
7
Isolation as a strategy for controlling the transmission of hepatitis C virus (HCV) infection in haemodialysis units.隔离作为血液透析单位控制丙型肝炎病毒（HCV）感染传播的一种策略。
Cochrane Database Syst Rev. 2016 Aug 11;2016(8):CD006420. doi: 10.1002/14651858.CD006420.pub2.
8
Population-based biomedical sexually transmitted infection control interventions for reducing HIV infection.基于人群的生物医学性传播感染控制干预措施以减少艾滋病毒感染。
Cochrane Database Syst Rev. 2011 Mar 16(3):CD001220. doi: 10.1002/14651858.CD001220.pub3.
9
Interventions to increase adherence to medications for tobacco dependence.提高烟草依赖药物依从性的干预措施。
Cochrane Database Syst Rev. 2015 Feb 23(2):CD009164. doi: 10.1002/14651858.CD009164.pub2.
10
Signs and symptoms to determine if a patient presenting in primary care or hospital outpatient settings has COVID-19.在基层医疗机构或医院门诊环境中，如果患者出现以下症状和体征，可判断其是否患有 COVID-19。
Cochrane Database Syst Rev. 2022 May 20;5(5):CD013665. doi: 10.1002/14651858.CD013665.pub3.

本文引用的文献

1
Adherence in Hepatitis C Virus Treatment: What We Know.丙型肝炎病毒治疗中的依从性：我们所了解的情况。
Semin Liver Dis. 2024 May;44(2):258-271. doi: 10.1055/a-2313-0111. Epub 2024 Apr 24.
2
Modeling the Impacts of Prevention and Treatment Interventions on Hepatitis C Among People Who Inject Drugs in China.模拟预防和治疗干预措施对中国注射吸毒人群丙型肝炎的影响。
Infect Dis Ther. 2023 Apr;12(4):1043-1055. doi: 10.1007/s40121-023-00779-0. Epub 2023 Mar 9.
3
Hepatitis C Virus Dynamic Transmission Models Among People Who Inject Drugs.
注射吸毒者中丙型肝炎病毒的动态传播模型
Infect Drug Resist. 2023 Feb 20;16:1061-1068. doi: 10.2147/IDR.S403133. eCollection 2023.
4
The and Architecture of the Hepatitis C Virus RNA Genome Uncovers Functional RNA Secondary and Tertiary Structures.丙型肝炎病毒 RNA 基因组的 和 结构揭示了功能性 RNA 二级和三级结构。
J Virol. 2022 Apr 27;96(8):e0194621. doi: 10.1128/jvi.01946-21. Epub 2022 Mar 30.
5
Modeling hepatitis C micro-elimination among people who inject drugs with direct-acting antivirals in metropolitan Chicago.在芝加哥大都市地区，使用直接作用抗病毒药物对注射吸毒者进行丙型肝炎微消除建模。
PLoS One. 2022 Mar 10;17(3):e0264983. doi: 10.1371/journal.pone.0264983. eCollection 2022.
6
The transmissibility of hepatitis C virus: a modelling study in Xiamen City, China.《中国厦门市丙型肝炎病毒传播性的建模研究》。
Epidemiol Infect. 2020 Nov 25;148:e291. doi: 10.1017/S0950268820002885.
7
Associations of health literacy with socioeconomic position, health risk behavior, and health status: a large national population-based survey among Danish adults.健康素养与社会经济地位、健康风险行为和健康状况的关联：丹麦成年人的一项大型全国性基于人群的调查。
BMC Public Health. 2020 Apr 28;20(1):565. doi: 10.1186/s12889-020-08498-8.
8
Hepatitis C virus modelled as an indirectly transmitted infection highlights the centrality of injection drug equipment in disease dynamics.丙型肝炎病毒被模拟为一种间接传播的感染，突出了注射毒品设备在疾病动态中的核心地位。
J R Soc Interface. 2019 Sep 27;16(158):20190334. doi: 10.1098/rsif.2019.0334. Epub 2019 Sep 4.
9
Mathematical modeling of hepatitis c virus (HCV) prevention among people who inject drugs: A review of the literature and insights for elimination strategies.丙型肝炎病毒（HCV）预防的数学建模：文献综述及消除策略的见解。
J Theor Biol. 2019 Nov 21;481:194-201. doi: 10.1016/j.jtbi.2018.11.013. Epub 2018 Nov 16.
10
Facilitators of HCV treatment adherence among people who inject drugs: a systematic qualitative review and implications for scale up of direct acting antivirals.注射吸毒者中丙型肝炎病毒治疗依从性的促进因素：一项系统的定性综述及对扩大直接抗病毒药物使用的启示
BMC Public Health. 2016 Sep 20;16:994. doi: 10.1186/s12889-016-3671-z.