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靶向β-葡聚糖,细胞壁的重要组成部分。

Targeting β-glucans, vital components of the cell wall.

机构信息

Department II of Infectious Diseases, Xixi Hospital of Hangzhou, Hangzhou, China.

Department of Infectious Diseases, State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang, China.

出版信息

Front Immunol. 2023 Feb 9;14:1094464. doi: 10.3389/fimmu.2023.1094464. eCollection 2023.

Abstract

β-glucan is the most abundant polysaccharide in the cell wall of , which has attracted extensive attention because of its unique immunobiological characteristics. β-glucan binds to various cell surface receptors, which produces an inflammatory response and accounts for its immune effects. A deeper comprehension of the processes by β-glucan recognizes its receptors, activates related signaling pathways, and regulates immunity as required. Such understanding will provide a basis for developing new therapies against . Herein, we briefly review the structural composition of β-glucans as a vital component of the cell wall, the host immunity mediated by β-glucans after their recognition, and discuss opportunities for the development of new strategies to combat .

摘要

β-葡聚糖是 的细胞壁中最丰富的多糖,由于其独特的免疫生物学特性而引起了广泛关注。β-葡聚糖与各种细胞表面受体结合,产生炎症反应,这是其免疫作用的基础。深入了解 β-葡聚糖识别其受体、激活相关信号通路以及根据需要调节免疫的过程,将为开发针对 的新疗法提供基础。在此,我们简要回顾了 β-葡聚糖作为 细胞壁重要组成部分的结构组成,以及其被识别后所介导的宿主免疫,并讨论了开发新策略来对抗 的机会。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a558/9947646/dae5ac3b7060/fimmu-14-1094464-g001.jpg

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