Wang Cui, Wang Yimin, Zeng Wen, Chen Hongbo, Pan Minghao, Shang Shaomei
Zhejiang Chinese Medical University School of Nursing, Hangzhou, Zhejiang Province, China.
Weihai Second Hospital Affiliated to Qingdao University Operating Room, Weihai, Shandong Province, China.
Sci Rep. 2025 Mar 6;15(1):7889. doi: 10.1038/s41598-025-92982-x.
The association between abdominal obesity and pulmonary function trajectories among patients with COPD remain to be unclear. This study aimed to explore the association between abdominal obesity and pulmonary function trajectories among patients with COPD. Data were collected from the China Health and Retirement Longitudinal Study, which was a nationally representative investigation. The pulmonary function indicator was peak expiratory flow (PEF). Abdominal obesity was assessed using waist circumference, which was categorized into two groups: < 90/85 cm and ≥ 90/85 cm, in men/women. Latent class growth analysis was used to identify distinct pulmonary function trajectories. The logistic regression was used to assess the association between abdominal obesity and pulmonary function trajectories. Finally, a total of 775 patients with COPD aged 45 years and older were included, and 301 participants (38.84%) were abdominal obesity. The mean PEF value showed a decreasing trend, with respective average values of 205.84 L/min (SD = 104.16), 199.99 L/min (SD = 99.52), and 196.06 L/min (SD = 86.74) in 2011, 2013 and 2015. Two PEF trajectories were identified: "above average-high descending" trajectory (n = 187, 24.13%) and "low-maintenance" trajectory (n = 588, 75.74%). Unadjusted and adjusted analysis showed that baseline higher waist circumference was associated with "low-maintenance" trajectory. A negative association between abdominal obesity and pulmonary function trajectories was observed among patients with COPD. This suggests that increased abdominal fat may accelerate the decline of pulmonary function over time. These findings provide evidence for designing targeted programs to improve pulmonary function, particularly for patients with COPD of abdominal obesity.
慢性阻塞性肺疾病（COPD）患者腹部肥胖与肺功能轨迹之间的关联仍不清楚。本研究旨在探讨COPD患者腹部肥胖与肺功能轨迹之间的关联。数据来自中国健康与养老追踪调查，这是一项具有全国代表性的调查。肺功能指标为呼气峰值流速（PEF）。采用腰围评估腹部肥胖，男性/女性腰围分为两组：<90/85厘米和≥90/85厘米。使用潜在类别增长分析来识别不同的肺功能轨迹。采用逻辑回归评估腹部肥胖与肺功能轨迹之间的关联。最终，共纳入775例年龄在45岁及以上的COPD患者，其中301例参与者（38.84%）存在腹部肥胖。PEF平均值呈下降趋势，2011年、2013年和2015年的平均值分别为205.84升/分钟（标准差=104.16）、199.99升/分钟（标准差=99.52）和196.06升/分钟（标准差=86.74）。识别出两条PEF轨迹：“高于平均水平-高下降”轨迹（n=187，24.13%）和“低维持”轨迹（n=588，75.74%）。未调整和调整分析均显示，基线时较高的腰围与“低维持”轨迹相关。在COPD患者中观察到腹部肥胖与肺功能轨迹之间存在负相关。这表明腹部脂肪增加可能会随着时间的推移加速肺功能下降。这些发现为设计针对性的改善肺功能计划提供了证据，特别是针对腹部肥胖的COPD患者。
