Zhang Lifang, Wang Jie, Grais Emad M, Li Yongxin, Zhao Fei
Department of Otolaryngology Head and Neck Surgery, Key Laboratory of Otolaryngology Head and Neck Surgery, Ministry of Education Beijing Tongren Hospital, Capital Medical University Beijing China.
Beijing Engineering Research Center of Audiological Technology Beijing China.
Laryngoscope Investig Otolaryngol. 2022 Dec 10;8(1):236-244. doi: 10.1002/lio2.988. eCollection 2023 Feb.
To investigate the effect of large vestibular aqueduct syndrome (LVAS) on middle ear sound transmission using wideband absorbance immittance (WAI).
WAI results from young adult LVAS patients and normal adults were compared.
Averaged energy absorbance (EA) at ambient and peak pressure in the LVAS group showed differences to the normal group. Under ambient pressure, the average EA of the LVAS group was significantly higher than the normal group at frequencies 472-866 Hz and 6169-8000 Hz ( < .05) and lower at frequencies 1122-2520 Hz ( < .05). Under peak pressure, absorbance was increased at frequencies 515-728, 841, and 6169-8000 Hz ( < .05) and decreased at 1122-1374 Hz and 1587-2448 Hz ( < .05). An investigation into the effect of external auditory canal pressure on EA across frequencies in the pressure-frequency domain, showed that EA differed significantly in the low-frequency region of 707and 1000 Hz from 0 to 200 daPa and 500 Hz at 50 daPa ( < .05). There was also a significant difference in EA between the two groups at 8000 Hz ( < .05) in the pressure range -200-300 daPa.
WAI is a valuable tool to measure the effect of LVAS on middle ear sound transmission. LVAS has a significant effect on EA at low and mid frequencies under ambient pressure, while the frequencies affected are mainly at low frequencies when positive pressure is presented.
Level 3a.
采用宽带吸收声导抗（WAI）研究大前庭导水管综合征（LVAS）对中耳声音传导的影响。
比较青年LVAS患者与正常成年人的WAI结果。
LVAS组在环境压力和峰值压力下的平均能量吸收率（EA）与正常组存在差异。在环境压力下，LVAS组在472 - 866Hz和6169 - 8000Hz频率处的平均EA显著高于正常组（P < 0.05），而在1122 - 2520Hz频率处则较低（P < 0.05）。在峰值压力下，515 - 728Hz、841Hz以及6169 - 8000Hz频率处的吸收率增加（P < 0.05），而在1122 - 1374Hz和1587 - 2448Hz频率处降低（P < 0.05）。在压力 - 频率域中，对外耳道压力对各频率EA的影响进行研究发现，在707Hz和1000Hz的低频区域，0至200daPa时EA存在显著差异，在50daPa时500Hz处也有显著差异（P < 0.05）。在 - 200 - 300daPa的压力范围内，两组在8000Hz处的EA也存在显著差异（P < 0.05）。
WAI是测量LVAS对中耳声音传导影响的一种有价值的工具。LVAS在环境压力下对低频和中频的EA有显著影响，而在施加正压时，受影响的频率主要在低频。
3a级。
