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PTPN18 通过增强免疫抑制作用成为胶质母细胞瘤的潜在癌基因。

PTPN18 Serves as a Potential Oncogene for Glioblastoma by Enhancing Immune Suppression.

机构信息

College of Life and Health Sciences, Northeastern University, Shenyang, Liaoning, China.

Research Laboratory Center, Guizhou Provincial People's Hospital, Guizhou University, Guiyang, Guizhou, China.

出版信息

Oxid Med Cell Longev. 2023 Feb 15;2023:2994316. doi: 10.1155/2023/2994316. eCollection 2023.

DOI:10.1155/2023/2994316
PMID:36846716
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9950791/
Abstract

Glioblastoma is characterized as one of the deadliest cancers in humans. The survival time is not improved by standard treatment. Although immunotherapy has revolutionized cancer treatment, the current therapy targets for glioblastoma patients are not satisfied. We systematically analyzed the expression patterns, predictive values, and immunological characteristics of PTPN18 in glioblastoma. The independent datasets and functional experiments were employed to validate our findings. Our data showed that PTPN18 is potentially cancerogenic in glioblastoma with advanced grades and poor prognosis. High expression of PTPN18 correlated with CD8 T cell exhaustion and immune suppression in glioblastoma. In addition, PTPN18 facilitates glioblastoma progression by accelerating glioma cell prefiltration, colony formation, and tumor growth in mice. PTPN18 also promotes cell cycle progression and inhibits apoptosis. Our results illustrate the characterization of PTPN18 in glioblastoma and highlight the potential value as an immunotherapeutic target for glioblastoma treatment.

摘要

胶质母细胞瘤是人类最致命的癌症之一。标准治疗并未改善患者的生存时间。尽管免疫疗法已经彻底改变了癌症治疗，但目前胶质母细胞瘤患者的治疗靶点仍不能令人满意。我们系统地分析了 PTPN18 在胶质母细胞瘤中的表达模式、预测价值和免疫学特征。我们利用独立数据集和功能实验来验证我们的发现。我们的数据表明，PTPN18 在高级别和预后不良的胶质母细胞瘤中具有潜在的致癌性。PTPN18 的高表达与 CD8 T 细胞耗竭和胶质母细胞瘤中的免疫抑制有关。此外，PTPN18 通过加速胶质瘤细胞预筛选、集落形成和小鼠肿瘤生长促进胶质母细胞瘤的进展。PTPN18 还促进细胞周期进程并抑制细胞凋亡。我们的结果说明了 PTPN18 在胶质母细胞瘤中的特征，并强调了其作为胶质母细胞瘤治疗免疫治疗靶点的潜在价值。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/40d1/9950791/974def0093e4/OMCL2023-2994316.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/40d1/9950791/893bbf9d2ad9/OMCL2023-2994316.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/40d1/9950791/dbd3c6fd866e/OMCL2023-2994316.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/40d1/9950791/6fd020d27f96/OMCL2023-2994316.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/40d1/9950791/2a4065207e2b/OMCL2023-2994316.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/40d1/9950791/09b08bd3416e/OMCL2023-2994316.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/40d1/9950791/974def0093e4/OMCL2023-2994316.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/40d1/9950791/893bbf9d2ad9/OMCL2023-2994316.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/40d1/9950791/dbd3c6fd866e/OMCL2023-2994316.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/40d1/9950791/6fd020d27f96/OMCL2023-2994316.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/40d1/9950791/2a4065207e2b/OMCL2023-2994316.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/40d1/9950791/09b08bd3416e/OMCL2023-2994316.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/40d1/9950791/974def0093e4/OMCL2023-2994316.006.jpg

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[1]
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Oxid Med Cell Longev. 2023

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引用本文的文献

[1]
Identifying Strong Neoantigen MHC-I/II Binding Candidates for Targeted Immunotherapy with SINE.

Int J Mol Sci. 2024-12-29

[2]
Mechanism of PTPN18 for regulating the migration and invasion of endometrial cancer cells via the MYC/PI3K/AKT pathway.

Histol Histopathol. 2025-2

本文引用的文献

[1]
Pan-cancer analyses of classical protein tyrosine phosphatases and phosphatase-targeted therapy in cancer.

Front Immunol. 2022

[2]
Nuclear import of PTPN18 inhibits breast cancer metastasis mediated by MVP and importin β2.

Cell Death Dis. 2022-8-18

[3]
PTPN18 promotes colorectal cancer progression by regulating the c-MYC-CDK4 axis.

Genes Dis. 2020-8-25

[4]
Increased infiltration of CD8 T cells in recurrent glioblastoma patients is a useful biomarker for assessing the response to combined bevacizumab and lomustine therapy.

Int Immunopharmacol. 2021-8

[5]
TANK-Binding Kinase 1 (TBK1) Serves as a Potential Target for Hepatocellular Carcinoma by Enhancing Tumor Immune Infiltration.

Front Immunol. 2021

[6]
Interactions of zinc- and redox-signaling pathways.

Redox Biol. 2021-5

[7]
Chinese Glioma Genome Atlas (CGGA): A Comprehensive Resource with Functional Genomic Data from Chinese Glioma Patients.

Genomics Proteomics Bioinformatics. 2021-2

[8]
Glioblastoma Immune Landscape and the Potential of New Immunotherapies.

Front Immunol. 2020

[9]
CBTRUS Statistical Report: Primary Brain and Other Central Nervous System Tumors Diagnosed in the United States in 2013-2017.

Neuro Oncol. 2020-10-30

[10]
Anti-PD-1 Induces M1 Polarization in the Glioma Microenvironment and Exerts Therapeutic Efficacy in the Absence of CD8 Cytotoxic T Cells.

Clin Cancer Res. 2020-9-1

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